Unsaturated Long‐Chain Fatty Acids Are Preferred Ferritin Ligands That Enhance Iron Biomineralization

Zanzoni, Serena; Pagano, Katiuscia; D’Onofrio, Mariapina; Assfalg, Michael; Ciambellotti, Silvia; Bernacchioni, Caterina; Turano, Paola; Aime, Silvio; Ragona, Laura; Molinari, Henríette

doi:10.1002/chem.201701164

Cited by 11 publications

(7 citation statements)

References 64 publications

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“…Further studies regarding the whole FA profile are encouraged. On the other hand, although we had data on fatty acid concentrations in plasma rather than red blood cells, we consider that our results are not affected because it has been shown that fatty acid concentrations in plasma and red blood cells are highly correlated [61][62][63] and studies that use both biochemical parameters obtained similar results [15]. Finally, we were unable to evaluate other environmental and genetic factors that might impact on serum fatty acid concentrations during pregnancy.…”

Section: Discussionmentioning

confidence: 73%

Maternal Factors Associated with Levels of Fatty Acids, Specifically n-3 PUFA during Pregnancy: ECLIPSES Study

et al. 2021

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An optimal fatty acid (FA) profile during pregnancy, especially docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), is essential for the health of the mother and child. Our aim was to identify the socioeconomic and maternal lifestyle factors associated with serum FA concentration in pregnant women. A longitudinal study was conducted on 479 pregnant women, who were assessed during the first (T1) and third (T3) trimesters of pregnancy. Data on maternal characteristics, food consumption, and lifestyle were collected. Serum FA concentrations were analysed by a gas chromatography–mass spectrometry combination. The multiple linear regression showed that high educational level and older age were significantly associated with higher EPA and DHA concentrations and lower values of n-6/n-3 and arachidonic acid (AA)/EPA in T1 and/or T3. Regarding diet—fish and seafood consumption increased EPA concentration and reduced n-6/n-3 and AA/EPA values in both trimesters, whereas its consumption increased DHA concentration only in T1. Smoking was associated with lower DHA concentration in T1 and higher values of n-6/n-3 ratio in both trimester. Overweight and obesity were associated with higher values of n-6/n-3 ratio and AA/EPA ratio in T1. A statistically non-significant association was observed with saturated fatty acids (SFA) and monounsaturated fatty acids (MUFA). In conclusion, high educational levels, older age, fish, seafood consumption, and/or non-smoking, are factors that influence better omega-3 polyunsaturated fatty acid (n-3 PUFA) profile in both trimesters of pregnancy. Further research is needed to go in-depth into these findings and their health consequences.

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Section: Discussionmentioning

confidence: 73%

Maternal Factors Associated with Levels of Fatty Acids, Specifically n-3 PUFA during Pregnancy: ECLIPSES Study

et al. 2021

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“…Furthermore, our study is a secondary analysis of a clinical trial of iron supplementation. In this sense, a physiological relationship between iron and fatty acids is hypostatized since, for instance, ferritin may incorporate FA in its structure in addition to iron [ 41 , 42 ]. However, our results did not show that the iron dosage of the supplementation had any effect on FA concentration.…”

Section: Discussionmentioning

confidence: 99%

Changes in fatty acid levels (saturated, monounsaturated and polyunsaturated) during pregnancy

Aparicio

Martín-Grau

Hernández‐Martínez

et al. 2021

BMC Pregnancy Childbirth

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Background During pregnancy a high amount of fatty acids (FA) is necessary to meet foetus demands, which vary during gestation. The present study describes the changes in maternal fatty acid concentrations during pregnancy in a sample of pregnant women. Methods This is a longitudinal study of 479 pregnant women who were monitored from the first trimester to third trimester of pregnancy. Data on maternal characteristics were recorded and a serum sample was collected in each trimester. The fatty acid profile (saturated (SFA: total, lauric acid, myristic acid, palmitic acid, stearic acid), monounsaturated (MUFA: total, palmitoleic acid, oleic acid) and polyunsaturated fatty acids (PUFA: total omega-6 (n-6), linoleic acid, dihomo-γ-linolenic acid, arachidonic acid (AA), total omega-3 (n-3), eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA)) was analysed with a gas chromatography-mass spectrometry combination. Results From the first trimester to third trimester of pregnancy, a significant increase in total SFA, total MUFA and total n-6 PUFA was found. (p < 0.001). Nevertheless, the serum concentration of arachidonic acid (AA), eicosapentaenoic acid (EPA) and total n-3 PUFA decreased during gestation (p < 0.001). A statistically non-significant result was observed for the docosahexaenoic acid (DHA) serum concentration between the first and third trimesters of pregnancy. Significant correlations were observed between each total fatty acid concentrations of the first and third trimesters. Conclusion The circulating serum concentration of SFA, MUFA and n-6 PUFA increases during pregnancy, whereas essential fatty acids such as AA and EPA decrease, and DHA remains unchanged. Further research is necessary to understand the role played by FA throughout gestation.

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“…Sodium arachidonate, ARA, was prepared by adding H 2 O (fluxed with nitrogen) directly to the vial obtained from the manufacturer to a concentration of 15 mM [63]. The solution was aliquoted in Wheaton glass serum bottles (Z113948) in 200-500 µL and clamped under nitrogen in a glovebox.…”

Section: Fatty Acid Samples Preparationmentioning

confidence: 99%

Unsaturated Fatty Acid-Induced Conformational Transitions and Aggregation of the Repeat Domain of Tau

et al. 2020

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Background: The intrinsically disordered, amyloidogenic protein Tau associates with diverse classes of molecules, including proteins, nucleic acids, and lipids. Mounting evidence suggests that fatty acid molecules could play a role in the dysfunction of this protein, however, their interaction with Tau remains poorly characterized. Methods: In a bid to elucidate the association of Tau with unsaturated fatty acids at the sub-molecular level, we carried out a variety of solution NMR experiments in combination with circular dichroism and fluorescence measurements. Our study shows that Tau4RD, the highly basic four-repeat domain of Tau, associates strongly with arachidonic and oleic acid assemblies in a high lipid/protein ratio, perturbing their supramolecular states and itself undergoing time-dependent structural adaptation. The structural signatures of Tau4RD/fatty acid aggregates appear similar for arachidonic acid and oleic acid, however, they are distinct from those of another prototypical intrinsically disordered protein, α-synuclein, when bound to these lipids, revealing protein-specific conformational adaptations. Both fatty acid molecules are found to invariably promote the self-aggregation of Tau4RD and of α-synuclein. Conclusions: This study describes the reciprocal influence that Tau4RD and fatty acids exert on their conformational states, contributing to our understanding of fundamental aspects of Tau/lipid co-assembly.

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Unsaturated Long‐Chain Fatty Acids Are Preferred Ferritin Ligands That Enhance Iron Biomineralization

Cited by 11 publications

References 64 publications

Maternal Factors Associated with Levels of Fatty Acids, Specifically n-3 PUFA during Pregnancy: ECLIPSES Study

Maternal Factors Associated with Levels of Fatty Acids, Specifically n-3 PUFA during Pregnancy: ECLIPSES Study

Changes in fatty acid levels (saturated, monounsaturated and polyunsaturated) during pregnancy

Unsaturated Fatty Acid-Induced Conformational Transitions and Aggregation of the Repeat Domain of Tau

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