Unspecific, idiopathic isolated osteolysis (Gorham–Stout syndrome) of the mandibular condylar process with its radiological, histological and clinical features: a case report and review of literature

Abstract

The unspecific and inconsistent clinical and radiological symptoms complicate the diagnosis of GD. Clinical, pathological and radiological correlation is essential to make the diagnosis. The different therapeutical options and the specific outcome are discussed.

Unilateral Creeping Destruction of Deformed Mandibular Ramus and Angle Associated with Extensive Facial Plexiform Neurofibroma in Neurofibromatosis Type 1: A Case Report with Analysis of the Literature for Diagnosing Osteolytic Events of the Mandible in Tumor-suppressor Gene Syndrome

“…Typically, the diagnosis of Gorham-Stout syndrome is made after the radiological findings and as a result of lack of evidence of neoplastic events in the affected region. Diagnosis requires synopsis of radiological, clinical, and histological findings (37). In the present case, only histological findings of the PNF were available.…”

“…Gorham-Stout syndrome is the eponymous term for describing the 'spontaneous' idiopathic dissolution of a bone, this means neoplastic, inflammatory, or other causes can be safely excluded after having applied adequate diagnostic procedures (33,34). Gorham-Stout syndrome has also been described in a few patients who had lost all or part of the lower jaw or temporomandibular joint region (35)(36)(37)(38)(39). The bone dissolution of the facial skull in Gorham-Stout syndrome is usually one-sided.…”