Multi-component effects, such as compressor-combustor interactions, are difficult to predict with computational fluid dynamics using reasonable computational resources due to the variety of physical phenomena, which have to be modeled. The approach described in the present study is to couple two separate flow solvers, a RANS flow solver computing the last stage of a compressor and an LES flow solver computing the prediffuser of a combustor. At the interface the flow solvers exchange the flow data in order to define each others boundary conditions at the interface plane. The use of multiple flow solvers allows the application of the most appropriate flow solver for each flow section. The present study describes the approach in general, the interface, which allows running multiple flow solvers, its validation, and presents its application to the compressor-diffuser example.