In this present article, we analyzed the Effects of Diffusion thermo and Thermal Diffusion on magnetohydrodynamic (MHD) mixed convection flow for Casson nanofluid is deliberated a vertical cone with porous material. The modeled equations are transformed into a set of non-linear ODEs by employing similar transformable variables. These equations are then solved numerically using the shooting method, through the fourth-order Runge–Kutta integration procedure. Effects of some prominent physical parameters, such as diffusion thermo, Prandtl number, thermophoresis parameter, and magnetic parameter on the velocity, temperature, and concentration profiles are discussed graphically and numerically. Numerical calculations and graphs are used to illustrate the important features of the solution on fluid flow velocity, heat, and mass transfer characteristics under different quantities of parametric circumstances entering into the problem. Moreover, we computed the physical variables such as the coefficient of shear stress, rate of heat, and mass transfer. To establish the veracity of our present results, we compared them to previously published research and found substantial concordance.