Unstimulated whole salivary flow rate and anxiolytics intake are independently associated with oral <i><scp>C</scp>andida</i> infection in patients with oral lichen planus

Bokor-Bratic, Marija; Čanković, Miloš; Dragnić, Nataša

doi:10.1111/eos.12073

Cited by 26 publications

(30 citation statements)

References 38 publications

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“…Mouth dryness is one of the most common oral health conditions and has been associated with OLP [8, 10, 12-16]. It may be attributed to xerostomia, salivary gland hypofunction (SGH) or both [17].…”

Section: Introductionmentioning

confidence: 99%

“…The literature pertaining to the associations between OLP and xerostomia and/or SGH is limited [8, 10, 12-16]. Some studies have demonstrated a relationship between OLP and SGH [10, 12-16].…”

Section: Introductionmentioning

confidence: 99%

“…Some studies have demonstrated a relationship between OLP and SGH [10, 12-16]. In a cross-sectional study, Lundström, et al .…”

Section: Introductionmentioning

confidence: 99%

“…Lastly, Bokor-Bratic, et al . studied USFRs in 90 OLP subjects and 90 age and sex matched controls and concluded that the mean USFR was within normal range compared to controls [12]. …”

Section: Introductionmentioning

confidence: 99%

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Xerostomia and Salivary Gland Hypofunction in Patients with Oral Lichen Planus Before and After Treatment with Topical Corticosteroids

Al-Janaby¹,

El-Sakka²,

Masood³

et al. 2017

TODENTJ

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Background:Oral lichen planus and mouth dryness are common pathoses, yet not entirely understood. These two conditions may be associated, with a few studies investigating the relationship between mouth dryness and oral lichen planus providing conflicting results. None of the studies have explored the specific impact of disease treatment on mouth dryness.Objective:The purpose of this observational before and after comparison study was to examine the effect of treatment of oral lichen planus with topical corticosteroids on mouth dryness.Methods:Nineteen subjects with oral lichen planus were evaluated for the severity of xerostomia using a xerostomia inventory and a visual analogue scale. Stimulated and unstimulated whole salivary flow rates, unstimulated salivary pH and buffering capacity were also measured. All subjects were evaluated before and after treatment with topical corticosteroids.Results:All subjects reported xerostomia before treatment with topical corticosteroids, with 79% reporting a significant improvement (P = 0.03) after treatment. Topical corticosteroid treatment was not associated with statistically significant differences in stimulated or unstimulated salivary flow rates, unstimulated salivary pH or buffering capacity.Conclusion:The results of this study suggest that treatment of oral lichen planus with topical corticosteroids may decrease the severity of dry mouth symptoms.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Some studies have demonstrated a relationship between OLP and SGH [10, 12-16]. In a cross-sectional study, Lundström, et al .…”

Section: Introductionmentioning

confidence: 99%

“…Lastly, Bokor-Bratic, et al . studied USFRs in 90 OLP subjects and 90 age and sex matched controls and concluded that the mean USFR was within normal range compared to controls [12]. …”

Section: Introductionmentioning

confidence: 99%

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Xerostomia and Salivary Gland Hypofunction in Patients with Oral Lichen Planus Before and After Treatment with Topical Corticosteroids

Al-Janaby¹,

El-Sakka²,

Masood³

et al. 2017

TODENTJ

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“…In recent years, the importance of pathogenic microorganisms such as Candida albicans in patients with lichen planus has been recognized (24)(25)(26)(27). Exfoliative cytology concerning surface cells is used for identifying the presence of abnormal cells, bacteria, and fungi.…”

Section: Cytological Assessmentmentioning

confidence: 99%

Oral lichen planus: a 4-year clinical follow-up study

Rimkevičius¹,

Aleksejūnienė²,

Pūrienė³

et al. 2017

Turk J Med Sci

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Background/aim: This study aimed to examine oral lichen planus (OLP) cases histopathologically and cytologically, describe different clinical aspects of OLP manifestations, and associate different OLP clinical forms with self-reported oral health and with local and systemic risk factors. Materials and methods:All patients with a referral diagnosis of OLP received biopsies. The histological evaluation assessed infiltration with lymphocytes, epithelial hyperplasia, and hyperkeratosis. Histology was used to validate the OLP diagnosis and to evaluate the malignant transformation of OLP lesions. Clinical manifestations of OLP and potential local oral environment-related risks were clinically assessed. Systemic risks were evaluated by a structured questionnaire.Results: A total of 133 patients with a histologically confirmed OLP diagnosis were followed. There were more females (N = 109) than males (N = 24) and the majority of patients were older than 50 years. The reticular form (45.1%) was the most prevalent clinical form followed by the erosive-ulcerative form (33.8%). The histological characteristics were most pronounced in the erosive-ulcerative form. Of the OLP cases, 2.3% had a malignant transformation. Conclusion:Reticular and erosive-ulcerative were the most prevalent OLP forms. There were more female than male OLP patients. Except for medication use, there were no statistically significant differences among different clinical OLP forms in either local or systemic risk factor distributions.

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“Exploring the Link Between Oral Lichen Planus and Xerostomia: A Systematic Literature Review”

AghaHosseini,

Tahmasebinasab,

Vatanpour

2024

Immunity Inflam & Disease

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IntroductionOral lichen planus (OLP) is a chronic disorder affecting the oral mucosa, potentially associated with xerostomia, either independently or concurrently. Research suggests that approximately 45% of patients with erythematous and ulcerative OLP may experience dry mouth sensations. The aim of this systematic review is to assess the current literature regarding the potential relationship or co‐occurrence of xerostomia with OLP. Understanding this association is imperative for the development of comprehensive management strategies and the improvement of patient outcomes.Method and MaterialThe study followed the PRISMA 2020 checklist and included human studies, specifically investigating xerostomia in patients with OLP. After screening 897 articles, 9 studies were selected based on predefined criteria Quality assessment was conducted using the Cochrane risk of bias tools: ROB 2 for RCTs and ROBINS‐I for non‐randomized studies Scale was conducted to evaluate potential biases in study design, selection, and outcomes.ResultA systematic review of nine studies (1960–2023) examining xerostomia in OLP patients found a significant reduction in unstimulated salivary flow rates in many cases. Although evidence links xerostomia with OLP, a definitive causal relationship remains unestablished. Some studies highlighted Candida infection, altered saliva protein expression, and inflammation‐related nerve damage as contributing factors to dry mouth in OLP patients.Discussion and ConclusionThis systematic review examines the potential relationship between OLP and xerostomia, focusing on factors such as salivary flow, histopathological changes, and immune‐related mechanisms. While some studies suggest a link between OLP and reduced saliva production, no definitive causal relationship has been established. The review identified significant research gaps, including inconsistent methodologies and a lack of standardized criteria. Future studies should explore different OLP forms, receptor interactions, immune responses, and neuropeptides to gain a better understanding of xerostomia's etiopathogenesis and improve management strategies for OLP patients.

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Unstimulated whole salivary flow rate and anxiolytics intake are independently associated with oral Candida infection in patients with oral lichen planus

Cited by 26 publications

References 38 publications

Xerostomia and Salivary Gland Hypofunction in Patients with Oral Lichen Planus Before and After Treatment with Topical Corticosteroids

Xerostomia and Salivary Gland Hypofunction in Patients with Oral Lichen Planus Before and After Treatment with Topical Corticosteroids

Oral lichen planus: a 4-year clinical follow-up study

“Exploring the Link Between Oral Lichen Planus and Xerostomia: A Systematic Literature Review”

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