Unsuccessful preoperative biopsies, fine needle aspiration cytology or core needle biopsy, lead to increased costs in the diagnostic workup in breast cancer

Hukkinen, Katja; Kivisaari, L.; Heikkilä, Päivi; Smitten, Karl von; Leidenius, Marjut

doi:10.1080/02841860802001442

Cited by 45 publications

(42 citation statements)

References 19 publications

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“…CNB is a routinely used method for preoperative assessment of breast cancer patients (1-3,5). CNB may not completely represent the biological profile of the tumor in all cases because of sampling errors (15), insufficient sample size of the CNB, fixation problems of RSs, intratumoral heterogeneity, and menopausal status of patients (3,5,8,9). The aim of this study was to assess the concordance of CNB and RS results and to clarify the reasons for discrepancies.…”

Section: Discussionmentioning

confidence: 99%

Concordance of immunohistochemistry between core needle biopsy and surgical resection of breast cancer

Kombak¹,

Şahin²,

Hande³

et al. 2017

Turk J Med Sci

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Background/aim: The purpose of this study was to evaluate the concordance of immunohistochemical (IHC) parameters of breast lesions between the core needle biopsy (CNB) and the surgical resection specimen.Materials and methods: CNB and resection specimens of female patients were retrospectively analyzed. ER, PR, HER-2, and Ki-67 parameters were compared for each patient. A total of 284 cases were assessed. Forty-one and 48 cases were excluded from the HER-2 and Ki-67 examinations, respectively, because the CNBs did not allow for IHC.Results: Concordance rates were 93.3% for ER, 89.4% for PR, 90.1% for HER-2, and 80.9% for Ki-67. Conclusion:CNB is accurate for the evaluation of the surrogate molecular profile of invasive breast cancer despite the heterogeneity of tumors.

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Section: Discussionmentioning

confidence: 99%

Concordance of immunohistochemistry between core needle biopsy and surgical resection of breast cancer

Kombak¹,

Şahin²,

Hande³

et al. 2017

Turk J Med Sci

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“…FNAC has average success rates of 75-90% for palpable and 34-58% for non-palpable breast lesions, whereas success rates reported for CNB are 97% and 94%, respectively (18,21,27). Another important criterion is represented by the lesion size.…”

Section: © C I C E D I Z I O N I I N T E R N a Z I O N A L Imentioning

confidence: 99%

Comparison between fine needle aspiration cytology (FNAC) and core needle biopsy (CNB) in the diagnosis of breast lesions

Moschetta¹,

Telegrafo²,

Da³

et al. 2014

GCHIR

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IntroductionBreast cancer still represents the leading tumor among women and the incidence of the disease is rising all over the world (1, 2). The risk of developing breast cancer is related to a number of factors including the events of reproductive life and lifestyle factors that modify endogenous levels of sex hormones. Diet has been also found to play an important role in the etiology of breast cancer.Mammography represents the most used modality for breast cancer screening, with mortality reduction of 30-40% in screened population (3, 4). However, its sensitivity is decreased in young women with radiologically dense breast (5). Another limitation of planar mammography is represented by the two-dimensional visualization of a three-dimensional volumetric structure such as the breast, with a consequent superimposition of tissue. These limitations are partially solved by the full-field digital mammography (FFDM), with its improved dynamic range, tissue contrast and post-processing, and by the digital breast tomosynthesis (DBT), which partially addresses the two-dimensional breast representation of planar mammography (4). Dual-energy contrast enhanced digital mammography represents a novel technique and has a reported sensitivity of 93% versus 78% of conventional mammography alone (6).With the recent advances in technology, US and MRI allow to delineate occult malignancy in women with dense breast tissue, especially in case of high risk patients (5,7,8).Recently, nuclear medicine imaging technology has been introduced in the field of breast cancer with the development of positron emission tomography (PET), PET- Aim. To compare the diagnostic accuracy of fine-needle aspiration cytology (FNAC) and core needle biopsy (CNB) in patients with USdetected breast lesions.Patients and methods. KEY WORDS: Breast -Fine-needle aspiration cytology -Core needle biopsy -FNAC -CNB.

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“…In the case of (potential) malignancy, the speed advantage of FNaC over CNB seems irrelevant in view of the required multidisciplinary meeting to arrive at a therapy plan. an interesting study showed that an indefinite diagnosis using FNaC required additional CNB and surgical excision biopsies in 32% and 21% of cases respectively (31 …”

Section: Cnb and Histopathology Of C3 (Atypia Probably Benign) Categomentioning

confidence: 99%

Comparative study of core needle biopsy and fine needle aspiration cytology in palpable breast lumps: scenario in developing nations

Tikku¹,

Umap²

2015

TJPATH

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Objective: The purpose of this study was to evaluate the utility of core needle biopsy as a diagnostic tool for palpable breast lumps in developing countries as compared to fine needle aspiration cytology .Material and Method: all patients attending the surgery outpatient department with palpable breast lumps were subjected to fine needle aspiration cytology and core needle biopsy by the same operator in a single session. Fine needle aspiration cytology was performed by the standard technique. Core needle biopsy was done freehand using a 14G manual core biopsy needle. reporting categories of the two techniques were taken from the standard National Health Service Breast Screening Programme criteria and were compared with the final histopathology results.Results: a total of 107 patients underwent fine needle aspiration cytology and core needle biopsy simultaneously. Histopathology was available for 85 cases. Statistical analysis of fine needle aspiration cytology and core needle biopsy showed no significant difference between the diagnoses offered by core needle biopsy and histopathology while there was a significant difference between fine needle aspiration cytology and histopathology diagnoses. Conclusion:Core needle biopsy detected more breast carcinomas as compared to fine needle aspiration cytology with a sensitivity 95.83% as opposed to 64.58%. Though both the techniques were equally specific (100%), Core needle biopsy was able to correctly categorize borderline / inadequate lesions into definitely benign and malignant categories. We suggest that core needle biopsy should be preferred over fine needle aspiration cytology for the diagnosis of palpable breast lumps with fine needle aspiration cytology being reserved for definitely benign lesions.

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Unsuccessful preoperative biopsies, fine needle aspiration cytology or core needle biopsy, lead to increased costs in the diagnostic workup in breast cancer

Cited by 45 publications

References 19 publications

Concordance of immunohistochemistry between core needle biopsy and surgical resection of breast cancer

Concordance of immunohistochemistry between core needle biopsy and surgical resection of breast cancer

Comparison between fine needle aspiration cytology (FNAC) and core needle biopsy (CNB) in the diagnosis of breast lesions

Comparative study of core needle biopsy and fine needle aspiration cytology in palpable breast lumps: scenario in developing nations

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