High-resolution coastline detection and monitoring are challenging on a global scale, especially in flat areas where natural events, sea level rise, and anthropic activities constantly modify the coastal environment. While the coastline related to the 0-level contour line can be extracted from accurate Digital Terrain Models (DTMs), the detection of the real-time, instantaneous coastline, especially at low tide, is a challenge that warrants further study and evaluation. In order to investigate an efficient combination of methods that allows to contribute to the knowledge in this field, this work uses topographic total station measurements, Global Navigation Satellite System Real-Time Kinematic (GNSS RTK) technique, and the Structure from Motion (SfM) approach (using a low-cost drone equipped with optical and thermal cameras). All the data were acquired at the beginning of 2022 and refer to the areas of Boccasette and Barricata, in the Po River Delta (Northeastern of Italy). The real-time coastline obtained from the GNSS data was validated using the topographic total station measurements; the correspondent polylines obtained from the photogrammetric data (using both automatic extraction and manual restitutions by visual inspection of orhophotos) were compared with the GNSS data to evaluate the performances of the different techniques. The results provided good agreement between the real-time coastlines obtained from different approaches. However, using the optical images, the accuracy was strictly connected with the radiometric changes in the photos and using thermal images, both manual and automatic polylines provided differences in the order of 1–2 m. Multi-temporal comparison of the 0-level coastline with those obtained from a LiDAR survey performed in 2018 provided the detection of the erosion and accretion areas in the period 2018–2022. The investigation on the two case studies showed a better accuracy of the GNSS RTK method in the real-time coastline detection. It can be considered as reliable ground-truth reference for the evaluation of the photogrammetric coastlines. While GNSS RTK proved to be more productive and efficient, optical and thermal SfM provided better results in terms of morphological completeness of the data.