In this study, the authors aimed to study an effective intelligent method for employment stability prediction in order to provide a reasonable reference for postgraduate employment decision and for policy formulation in related departments. First, this paper introduces an enhanced slime mould algorithm (MSMA) with a multi-population strategy. Moreover, this paper proposes a prediction model based on the modified algorithm and the support vector machine (SVM) algorithm called MSMA-SVM. Among them, the multi-population strategy balances the exploitation and exploration ability of the algorithm and improves the solution accuracy of the algorithm. Additionally, the proposed model enhances the ability to optimize the support vector machine for parameter tuning and for identifying compact feature subsets to obtain more appropriate parameters and feature subsets. Then, the proposed modified slime mould algorithm is compared against various other famous algorithms in experiments on the 30 IEEE CEC2017 benchmark functions. The experimental results indicate that the established modified slime mould algorithm has an observably better performance compared to the algorithms on most functions. Meanwhile, a comparison between the optimal support vector machine model and other several machine learning methods on their ability to predict employment stability was conducted, and the results showed that the suggested the optimal support vector machine model has better classification ability and more stable performance. Therefore, it is possible to infer that the optimal support vector machine model is likely to be an effective tool that can be used to predict employment stability.