Unsuspected Lung Pathology in Autopsies of Children with Cancer

Furuya, María E.Y.; Rodríguez-Velasco, Alicia; Rodriguez-Zepeda, M C; López-Aguilar, Enrique; Vargas, Mario H.; Sciandra-Rico, Martha; Cárdenas-Navarrete, Rocío; Madrigal-Muñiz, Olivia; Feria-Kaiser, Carina; Delgado-González, Elba E; Villasís-Keever, Miguel Ángel

doi:10.24875/ric.17002098

Cited by 1 publication

(1 citation statement)

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“…Diffuse alveolar hemorrhage, a rare but severe non‐infectious complication of hematopoietic cell transplantation (HCT), presents with respiratory failure and hemoptysis around the time of white blood cell engraftment, and is associated with a high mortality rate . A recent study on autopsies of children with cancer found a high incidence of pulmonary hemorrhage (40%), this being the most frequently missed clinical diagnosis . The absence of hemoptysis does not exclude a diagnosis of diffuse alveolar hemorrhage in adults; this may also be true for children.…”

Section: Cardiothoracic Oncologic Emergenciesmentioning

confidence: 99%

Pediatric oncologic emergencies: Clinical and imaging review for pediatricians

Handa

Nozaki

Makidono

et al. 2019

Pediatrics International

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Children with cancer are at increased risk of life-threatening emergencies, either from the cancer itself or related to the cancer treatment. These conditions need to be assessed and treated as early as possible to minimize morbidity and mortality. Cardiothoracic emergencies encompass a variety of pathologies, including pericardial effusion and cardiac tamponade, massive hemoptysis, superior vena cava syndrome, pulmonary embolism, and pneumonia. Abdominal emergencies include bowel obstruction, intussusception, perforation, tumor rupture, intestinal graftversus-host disease, acute pancreatitis, neutropenic colitis, and obstructive uropathy. Radiology plays a vital role in the diagnosis of these emergencies. We here review the clinical features and imaging in pediatric patients with oncologic emergencies, including a review of recently published studies. Key radiological images are presented to highlight the radiological approach to diagnosis. Pediatricians, pediatric surgeons, and pediatric radiologists need to work together to arrive at the correct diagnosis and to ensure prompt and appropriate treatment strategies.

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Section: Cardiothoracic Oncologic Emergenciesmentioning

confidence: 99%