Unsuspected small ameloblastoma in the alveolar bone: a collaborative study of 14 cases with discussion of their cellular sources

Ide, Fumio; Mishima, Kenji; Yamada, Hiroyuki; Horie, Norio; Shimoyama, Tetsuo; Kusama, Kaoru

doi:10.1111/j.1600-0714.2007.00628.x

Cited by 14 publications

(18 citation statements)

References 33 publications

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“…The clinical and radiographic aspects of UA are not specific and can be seen in odontogenic cysts [1, 3]. In these circumstances, identification of this frequently underdiagnosed cystic tumor often comes from after recurrence [5–8].…”

Section: Discussionmentioning

confidence: 99%

Diagnostically Challenging Epithelial Odontogenic Tumors: A Selective Review of 7 Jawbone Lesions

Ide

Mishima

Saito

et al. 2009

Head and Neck Pathol

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Considerable variation in the clinicopathologic presentation of epithelial odontogenic tumors can sometimes be confusing and increase the chance of misdiagnosis. Seven diagnostically challenging jawbone lesions are described. There were 2 cases of mistaken identity in our ameloblastoma file. One unicystic type, initially diagnosed and treated as a lateral periodontal cyst, showed destructive recurrence 6 years postoperatively. The other globulomaxillary lesion was managed under the erroneous diagnosis of adenomatoid odontogenic tumor and recurred 4 times over an 11-year period. This tumor was found in retrospect to be consistent with an adenoid ameloblastoma with dentinoid. The diagnosis of cystic squamous odontogenic tumor (SOT) occurring as a radicular lesion of an impacted lower third molar was one of exclusion. Of two unsuspected keratocystic odontogenic tumors, one depicted deceptive features of pericoronitis, while the other case has long been in our files with the diagnosis of globulomaxillary SOT. Two cases of primary intraosseous squamous cell carcinoma appeared benign clinically and exhibited unexpected findings; an impacted third molar began to erupt in association with the growth of carcinoma and another periradicular carcinoma showed dentinoid formation. Cases selectively reviewed in this article present challenging problems which require clinical and radiographic correlation to avoid potential diagnostic pitfalls.

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Section: Discussionmentioning

confidence: 99%

Diagnostically Challenging Epithelial Odontogenic Tumors: A Selective Review of 7 Jawbone Lesions

Ide

Mishima

Saito

et al. 2009

Head and Neck Pathol

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“…Such epithelial residues, either in the alveolar bone surface or in the cervical or middle portion of the periodontal ligament, seem likely starting points of our cases. The previous observations that ameloblastomatoid rests appeared later in adult life and tended to increase with age lend credence to the occurrence in an older age range [2,[25][26][27][28][29].…”

Section: Discussionmentioning

confidence: 95%

“…With regard to the histogenesis, the rests of Malassez inside or outside the periodontal ligament space may be a potential candidate [2,[24][25][26][27][28][29]. Such epithelial residues, either in the alveolar bone surface or in the cervical or middle portion of the periodontal ligament, seem likely starting points of our cases.…”

Section: Discussionmentioning

confidence: 99%

“…There are many indications in the literature concerning unsuspected small IA of the tooth-bearing part of the jawbone [2,4,[13][14][15][16][17][18][19]. Given that the surrounding alveolar bone provides more resistance to tumor growth than does the gingiva, infiltrating IA has a tendency to extend into the overlying mucosa, either directly or along the periodontal ligament, once tumor nests penetrate the bony confine.…”

Section: Discussionmentioning

confidence: 99%

“…Ameloblastoma can be encountered in any area of the jaws from the body of bone through the alveolar crest to the gingiva [1,2], and between 1 and 10% of cases are reported to occur peripherally [3]. By definition, peripheral ameloblastoma (PA) does not spread beyond the gingival submucosa into the alveolar bone [1,3].…”

Section: Introductionmentioning

confidence: 99%

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Intraosseous Ameloblastoma with a Prominent Extraosseous Component: Pitfalls in Diagnosis

Ide

Mishima

Yamada

et al. 2010

Head and Neck Pathol

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For many years, gingival tumors of what appear to be peripherally located intraosseous ameloblastoma (IA) arising from the alveolar bone surface have often been confused with peripheral ameloblastoma (PA) causing resorption of the underlying bone. We analyzed a series of five cases of ameloblastoma that demonstrated a combined PA and IA architecture. The tumor commonly involved the anterior-premolar area, mostly in the maxilla and mainly in middle-aged men. The clinical presentation was an exophytic gingival mass inferior to which was a small bone defect. The predominant extraosseous component showed a papillary gross surface, reflecting the histologic proof of fusion between the submucosal tumor and the surface epithelium. In addition to the PA-like growth pattern, common to all was the presence of neoplastic destruction of the alveolar process, corresponding to an associated radiolucent lesion. This restrained component was acceptable as IA. In two cases, recurrence was observed deep in the alveolar bone with no involvement of the gingiva. These tumors appear to be IA that arose from the marginal alveolar bone and grew preferentially in the gingiva, forming a PA-like appearance. From diagnostic, therapeutic and prognostic points of view, this type of IA should not be confused with PA.

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Revisiting the human dental follicle: From tooth development to its association with unerupted or impacted teeth and pathological changes

Bastos

Gomez

Gomes

2021

Developmental Dynamics

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Dental follicles are involved in odontogenesis, periodontogenesis, and tooth eruption. Dental follicles are unique structures, considering that their remnants can persist within the jawbones after odontogenesis throughout life if the tooth does not erupt. Pathological changes may occur in these tissues as individuals age. The changes range from benign to life threatening. Thus, the assessment of age-related changes in dental follicles associated with unerupted teeth is of paramount importance. In this review, we summarize the physiological roles and changes in dental follicles in odontogenesis, tooth eruption, and aging, in addition to the pathological changes associated with these structures. We encourage investigators to consider this peculiar tissue as a unique model and explore its potential to clarify its importance from the viewpoints of developmental biology, tissue physiology, and pathology.

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Unsuspected small ameloblastoma in the alveolar bone: a collaborative study of 14 cases with discussion of their cellular sources

Cited by 14 publications

References 33 publications

Diagnostically Challenging Epithelial Odontogenic Tumors: A Selective Review of 7 Jawbone Lesions

Diagnostically Challenging Epithelial Odontogenic Tumors: A Selective Review of 7 Jawbone Lesions

Intraosseous Ameloblastoma with a Prominent Extraosseous Component: Pitfalls in Diagnosis

Revisiting the human dental follicle: From tooth development to its association with unerupted or impacted teeth and pathological changes

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