Unsuspected Uterine Metastasis of Breast Carcinoma Diagnosed by 18F-FDG PET/CT

Muñoz-Iglesias, J.; Uña-Gorospe, J.; Allende-Riera, A.; Sequera-Rahola, Marta De; Cárdenas-Negro, C.

doi:10.1097/rlu.0b013e318292a73b

Cited by 4 publications

(4 citation statements)

References 10 publications

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“…This case indicates uterine lymphoma should be included in the differential diagnosis of abnormal uterine FDG accumulation along with physiological endometrial uptake, 11 postpartum uterus, 12 adenomyosis, 13,14 endometrial hyperplasia, 14 leiomyoma, 14,15,16 cervical cancer, 14,17 endometrial cancer, 14,18 choriocarcinoma, 19 uterine sarcoma, 14,16,20 and uterine metastasis. 14,21 …”

Section: Discussionmentioning

confidence: 99%

Primary Uterine Peripheral T-cell Lymphoma

Gong¹,

Dong

Wei³

et al. 2016

Medicine

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Primary uterine non-Hodgkin's lymphoma is extremely rare accounting for <1% of all extranodal non-Hodgkin's lymphomas. Imaging findings of primary uterine lymphoma have rarely been reported before. We present magnetic resonance imaging (MRI) and fluorine-18-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET)/CT findings in a patient with primary uterine peripheral T-cell lymphoma.A 27-year-old female presented with intermittent fever with neutropenia for 7 months. MRI showed an ill-defined mass involved both the uterine corpus and cervix, resulting in diffuse enlargement of the uterus. This mass showed inhomogeneous hypointensity on unenhanced T1-weighted images, hyperintensity on diffusion-weighted imaging, relative hypointensity compared to the surrounding myometrium on T2-weighted images and lower enhancement than the surrounding myometrium on enhanced T1-weighted images. FDG PET/CT showed intense FDG uptake in the thickened wall of the uterine corpus and cervix with SUVmax of 26.9. There were multiple hypermetabolic lymph nodes in the pelvis and retroperitoneum. Uterine curettage and CT-guided biopsy of the uterine mass revealed peripheral T-cell lymphoma. Bone marrow biopsy revealed no evidence of lymphomatous involvement. The imaging and pathologic findings were consistent with primary uterine lymphoma. After 3 circles of chemotherapy, follow-up enhanced MRI showed decreased thickness of the uterine wall.Despite its rarity, primary uterine non-Hodgkin's lymphoma should be taken into consideration when a uterine tumor shows large size, relative hypointesity on both T2-weighted images and enhanced T1-weighted images compared to the surrounding myometrium, and intense FDG uptake on PET/CT. MRI may be helpful for describing the relationship between the tumor and adjacent structures. FDG PET/CT may be useful for tumor detection and staging.

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Section: Discussionmentioning

confidence: 99%

Primary Uterine Peripheral T-cell Lymphoma

Gong¹,

Dong

Wei³

et al. 2016

Medicine

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“…However, the increased uptake in a postmenopausal woman should raise the suspicion of malignancy and initiate further workup. In this study, the case reported by Muñoz-Iglesias et al [14] had no uterine symptoms, but the progressive elevation of tumor markers after 6 years of management of bilateral lobular carcinoma of the breast led to PET-CT and the discovery of uterine metastasis. In the cases reported by Thouvenot et al [34], D'souza et al [6], and Danolić et al [45] , PET-CT revealed widespread metastatic lesions.…”

Section: Discussionmentioning

confidence: 55%

Uterine Metastasis from Carcinoma of Breast – A Systematic Analysis

et al. 2023

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Breast cancer can metastasize to a wide range of organs, but reports about uterine metastases are rare. The current article systematically analyzes 55 patients reported in peer-reviewed literature from 2010–2022 with respect to nine variables, including: [i] age of the patient; [ii] clinical presentation of uterine metastasis; [iii] precise location of metastasis; [iv] primary (breast) cancer histopathology; [v] imaging modality utilized for detection of metastasis; [vi] timing of appearance of metastases: synchronous or metachronous; [vii] immunochemistry markers; [viii] management; and [ix] survival. Uterine metastases may appear in synchronous or metachronous fashion and may be asymptomatic or have symptoms like abnormal vaginal bleeding. Treatment of uterine metastases usually comprises of total abdominal hysterectomy with bilateral salpingo-oophorectomy along with chemotherapy. The long-term prognosis is unclear, but due to the development of metastases in other bodily parts, cases frequently have a poor outcome.

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“…İşçi et al, [13] 2011 47 ILC + -YES (letrozole) During the follow-up CT Surgery + chemotherapy Dirican et al, [14] 2012 51 IDC -+ YES (tamoxifen) During the follow-up CT + tumor marker Surgery + chemotherapy van et al, [15] 2012 70 IDC NA NA YES (tamoxifen) During the follow-up CT Surgery Munoz-Iglesias et al, [16] 2013 50 ILC NA NA YES (NA) During the follow-up Tumor marker + PET/CT Surgery Proenca et al, [17] The female reproductive system is rarely affected by metastasis. The most common site of metastasis is the ovary, followed by the vagina (75.8% and 13.4%).…”

Section: Mri Chemotherapy + Radiotherapymentioning

confidence: 99%

Asymptomatic uterine metastasis of breast cancer: Case report and literature review

et al. 2022

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Rationale: Uterine metastasis from breast cancer is extremely rare. Asymptomatic patients with cervical metastases from breast cancer are rarer and more likely to be missed. We present an asymptomatic patient with breast cancer metastasized to the uterus and share opinions on diagnosing and treating for this kind of cases. Patient concerns: We present the case of a 64-year-old woman who was diagnosed with both breast cancer and uterine fibroids after examination. She had no symptoms of gynecological disease during breast cancer treatment. A positron emission tomography/computed tomography (PET/CT) scan was performed during reexamination, revealing multiple metastases of the bone throughout the body and an abnormal hypermetabolic mass in the uterus. It was later confirmed as uterine metastasis by pathology. Diagnosis: A diagnosis of metastatic breast invasive lobular carcinoma was established after a uterine curettage. Interventions and outcomes: Treatment of the uterine metastasis included systemic chemotherapy, total abdominal hysterectomy and bilateral salpingo-oophorectomy (TAH and BSO), postoperative radiotherapy, and postoperative chemotherapy. The patient eventually refused further treatment for personal reasons and died at home. Lessons: Breast cancer metastases to the uterus are very rare and further research is needed for their diagnosis and treatment. During reexamination of breast cancer patients, clinicians must be alert to metastasis to gynecologic organs. This is particularly important in hormone receptor-positive patients with asymptomatic distant metastasis.

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Unsuspected Uterine Metastasis of Breast Carcinoma Diagnosed by 18F-FDG PET/CT

Cited by 4 publications

References 10 publications

Primary Uterine Peripheral T-cell Lymphoma

Primary Uterine Peripheral T-cell Lymphoma

Uterine Metastasis from Carcinoma of Breast – A Systematic Analysis

Asymptomatic uterine metastasis of breast cancer: Case report and literature review

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