Untangling the complexity of heat shock protein 27 in cancer and metastasis

Rizvi, Suroor Fatima; Hasan, Adria; Parveen, Sana; Mir, Snober S.

doi:10.1016/j.abb.2023.109537

Cited by 7 publications

(3 citation statements)

References 160 publications

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“…A 32.46% decrease in HSP70 expression in the ES group, compared to the NS group, indicates that ES treatment leads to the down-regulation of HSP70 expression in the meat. Proteomic studies have correlated HSP70 with meat tenderness, where lower expression levels are associated with reduced shear force [ 36 ]. The up-regulation of HSPs in stiffer meat corresponds to the lower shear force value observed in the ES group in this study.…”

Section: Resultsmentioning

confidence: 99%

Electrical Stimulation Induces Activation of Mitochondrial Apoptotic Pathway and Down-Regulates Heat Shock Proteins in Pork: An Innovative Strategy for Enhancing the Ripening Process and Quality of Dry-Cured Loin Ham

Yue,

Bi,

et al. 2024

Foods

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A fundamental regulatory framework to elucidate the role of electrical stimulation (ES) in reducing long production cycles, enhancing protein utilization, and boosting product quality of dry-cured ham is essential. However, how mitochondria and enzymes in meat fibers are altered by ES during post-processing, curing, and fermentation procedures remains elusive. This study sought to explore the impact of ES on the regulation of heat shock proteins (HSP27, HSP70), apoptotic pathways, and subsequent influences on dry-cured pork loin quality. The gathered data validated the hypothesis that ES notably escalates mitochondrial oxidative stress and accelerates mitochondrial degradation along the ripening process. The proapoptotic response in ES-treated samples was increased by 120.7%, with a cellular apoptosis rate 5-fold higher than that in control samples. This mitochondrial degradation is marked by increased ratios of Bax/Bcl-2 protein along the time course, indicating that apoptosis could contribute to the dry-cured ham processing. ES was shown to further down-regulate HSP27 and HSP70, establishing a direct correlation with the activation of mitochondrial apoptosis pathways, accompanied by dry-cured ham quality improvements. The findings show that ES plays a crucial role in facilitating the ripening of dry-cured ham by inducing mitochondrial apoptosis to reduce HSP expression. This knowledge not only explains the fundamental mechanisms behind myofibril degradation in dry-cured ham production but also offers a promising approach to enhance quality and consistency.

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Section: Resultsmentioning

confidence: 99%

Electrical Stimulation Induces Activation of Mitochondrial Apoptotic Pathway and Down-Regulates Heat Shock Proteins in Pork: An Innovative Strategy for Enhancing the Ripening Process and Quality of Dry-Cured Loin Ham

Yue,

Bi,

et al. 2024

Foods

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“…An important epithelial junction-dependent mechanism, which is controlled by Hsp27, is the EMT of epithelial-derived cancer cells. Hsp27 is commonly upregulated in different tumors [ 153 , 154 ], and its effects on tumor cell behavior have been investigated by using knockdown and overexpression approaches. Downregulation of HSPB1/Hsp27 expression by RNA interference increased the expression of a key AJ protein, E-cadherin, in colorectal, pancreatic ductal, and prostate cancer cells [ 155 , 156 , 157 ].…”

Section: Hspb (Small Heat Shock Proteins)mentioning

confidence: 99%

Regulation of Epithelial and Endothelial Barriers by Molecular Chaperones

Lechuga,

Marino-Melendez,

Naydenov

et al. 2024

Cells

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The integrity and permeability of epithelial and endothelial barriers depend on the formation of tight junctions, adherens junctions, and a junction-associated cytoskeleton. The establishment of this junction–cytoskeletal module relies on the correct folding and oligomerization of its protein components. Molecular chaperones are known regulators of protein folding and complex formation in different cellular compartments. Mammalian cells possess an elaborate chaperone network consisting of several hundred chaperones and co-chaperones. Only a small part of this network has been linked, however, to the regulation of intercellular adhesions, and the systematic analysis of chaperone functions at epithelial and endothelial barriers is lacking. This review describes the functions and mechanisms of the chaperone-assisted regulation of intercellular junctions. The major focus of this review is on heat shock protein chaperones, their co-chaperones, and chaperonins since these molecules are the focus of the majority of the articles published on the chaperone-mediated control of tissue barriers. This review discusses the roles of chaperones in the regulation of the steady-state integrity of epithelial and vascular barriers as well as the disruption of these barriers by pathogenic factors and extracellular stressors. Since cytoskeletal coupling is essential for junctional integrity and remodeling, chaperone-assisted assembly of the actomyosin cytoskeleton is also discussed.

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“…Although the assessment of circulating biomarkers in stable conditions is encouraging, even more promising would be the assessment of changes in biomarker concentration after stress-induced ischemia, for example by incorporating blood sample collections in stress imaging protocols. This is especially important when assess-ing cardiac ischemia as most biomarkers discussed in this paper are not cardiac-specific and their baseline concentration may be confounded by other conditions such as autoimmune or neoplastic disorders or chronic obstructive pulmonary disease [47][48][49][50].…”

Section: Contemporary and Future Roles Of Biomarkers In Cadmentioning

confidence: 99%

Circulating biomarkers in the setting of stress test-induced myocardial ischemia – a review of potential candidates for introduction into clinical practice

Zandecki,

Zachura,

Barańska

et al. 2024

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The essential goal in the diagnostic approach to chronic coronary syndromes is to identify patients with significant stenoses in the coronary arteries who could benefit from invasive treatment while avoiding exposure to unnecessary interventional treatments or diagnostic procedures for patients who are unlikely to have significant stenoses in their coronary arteries. Early myocardial ischemia leads to a dynamic molecular response in the affected myocardium. A promising minimally invasive strategy is to access changes of concentrations of certain biomarkers circulating in blood during stress test-induced myocardial ischemia. This novel approach may change the landscape of non-invasive assessment of cardiac ischemia. However, there is a need for careful selection of possible candidates to be evaluated in future clinical trials. Several biomarkers have been proposed as potentially useful in this context and they are discussed in this review paper. StreszczeniePodstawowym celem w diagnostyce przewlekłych zespołów wieńcowych jest identyfikacja pacjentów z istotnymi zwężeniami w tętnicach wieńcowych, którzy mogliby odnieść korzyść z leczenia inwazyjnego, unikając jednocześnie narażenia na niepotrzebne inwazyjne procedury diagnostyczne lub lecznicze pacjentów, którzy prawdopodobnie nie mają istotnych zwężeń w tętnicach wieńcowych. Niedokrwienie mięśnia sercowego już na wczesnym etapie prowadzi do dynamicznej odpowiedzi na poziomie molekularnym. Obiecującą minimalnie inwazyjną strategią jest ocena zmian stężeń pewnych biomarkerów krążących we krwi podczas niedokrwienia mięśnia sercowego wywołanego testem wysiłkowym. To nowatorskie podejście może zmienić strategie nieinwazyjnej oceny niedokrwienia serca. Potrzebna jest staranna selekcja potencjalnych kandydatów do oceny w badaniach klinicznych. Co najmniej kilka biomarkerów zaproponowano jako potencjalnie użyteczne w tym zakresie i omówiono w niniejszym artykule przeglądowym.

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Untangling the complexity of heat shock protein 27 in cancer and metastasis

Cited by 7 publications

References 160 publications

Electrical Stimulation Induces Activation of Mitochondrial Apoptotic Pathway and Down-Regulates Heat Shock Proteins in Pork: An Innovative Strategy for Enhancing the Ripening Process and Quality of Dry-Cured Loin Ham

Electrical Stimulation Induces Activation of Mitochondrial Apoptotic Pathway and Down-Regulates Heat Shock Proteins in Pork: An Innovative Strategy for Enhancing the Ripening Process and Quality of Dry-Cured Loin Ham

Regulation of Epithelial and Endothelial Barriers by Molecular Chaperones

Circulating biomarkers in the setting of stress test-induced myocardial ischemia – a review of potential candidates for introduction into clinical practice

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