2023
DOI: 10.1101/2023.04.03.535491
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Untangling the mechanisms of pulmonary hypertension-induced right ventricular stiffening in a large animal model

Abstract: Background: Pulmonary arterial hypertension (PHT) is a devastating disease with low survival rates. In PHT, chronic pressure overload leads to right ventricle (RV) remodeling and stiffening; thus, impeding diastolic filling and ventricular function. Multiple mechanisms contribute to RV stiffening, including wall thickening, microstructural disorganization, and myocardial stiffening. The relative importance of each mechanism is unclear. Our objective is to use a large animal model as well as experimental and co… Show more

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