Untangling the neurobiology of coping styles in rodents: Towards neural mechanisms underlying individual differences in disease susceptibility

Boer, Sietse F. de; Buwalda, Bauke; Koolhaas, Jaap M.

doi:10.1016/j.neubiorev.2016.07.008

Cited by 130 publications

(87 citation statements)

References 195 publications

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“…Sometimes, agonistic behaviour towards a conspecific and its correlation with behaviour in other contexts is studied as well [40, 44, 48]. Agonistic behaviour and boldness can also be correlated with various physiological stress markers, such as corticosterone levels or the heart rate response to stress, which is larger in more aggressive animals [32, 50–52]. The structural consistency is not studied so often in comparison with the differential one.…”

Section: Introductionmentioning

confidence: 99%

Development of behavioural profile in the Northern common boa (Boa imperator): Repeatable independent traits or personality?

et al. 2017

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Recent studies of animal personality have focused on its proximate causation and ecological and evolutionary significance in particular, but the question of its development was largely overlooked. The attributes of personality are defined as between-individual differences in behaviour, which are consistent over time (differential consistency) and contexts (contextual generality) and both can be affected by development. We assessed several candidates for personality variables measured in various tests with different contexts over several life-stages (juveniles, older juveniles, subadults and adults) in the Northern common boa. Variables describing foraging/feeding decision and some of the defensive behaviours expressed as individual average values are highly repeatable and consistent. We found two main personality axes—one associated with foraging/feeding and the speed of decision, the other reflecting agonistic behaviour. Intensity of behaviour in the feeding context changes during development, but the level of agonistic behaviour remains the same. The juveniles and adults have a similar personality structure, but there is a period of structural change of behaviour during the second year of life (subadults). These results require a new theoretical model to explain the selection pressures resulting in this developmental pattern of personality. We also studied the proximate factors and their relationship to behavioural characteristics. Physiological parameters (heart and breath rate stress response) measured in adults clustered with variables concerning the agonistic behavioural profile, while no relationship between the juvenile/adult body size and personality concerning feeding/foraging and the agonistic behavioural profile was found. Our study suggests that it is important for studies of personality development to focus on both the structural and differential consistency, because even though behaviour is differentially consistent, the structure can change.

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Section: Introductionmentioning

confidence: 99%

Development of behavioural profile in the Northern common boa (Boa imperator): Repeatable independent traits or personality?

et al. 2017

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“…Differences between the coping styles were found in numerous studies in the context of behavior (Koolhaas et al, 1999), physiology (Hessing et al, 1994a; Ruis et al, 2000), immune responses (Oster et al, 2015) and genetic variants (Ponsuksili et al, 2015). Coping behavior associated with detailed autonomic regulation remains largely understudied (for review, see Koolhaas et al, 1999, 2010; de Boer et al, 2017). In the present article, we used behavioral differences, resulting in proactive or reactive coping patterns, to identify phenotypes related to autonomic responses during different behavioral contexts.…”

Section: Introductionmentioning

confidence: 99%

Coping Style Modifies General and Affective Autonomic Reactions of Domestic Pigs in Different Behavioral Contexts

Krause

Puppe

Langbein

2017

Front. Behav. Neurosci.

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Based on individual adaptive strategies (coping), animals may react differently to environmental challenges in terms of behavior and physiology according to their emotional perception. Emotional valence as well as arousal may be derived by measuring vagal and sympathetic tone of the autonomic nervous system (ANS). We investigated the situation-dependent autonomic response of 16 domestic pigs with either a reactive or a proactive coping style, previously selected according to the backtest which is accepted in piglets to assess escape behavior. At 11 weeks of age, the pigs were equipped with an implantable telemetric device, and heart rate (HR), blood pressure (BP) and their respective variabilities (HRV, BPV) were recorded for 1 h daily over a time period of 10 days and analyzed in four behavioral contexts (resting, feeding, idling, handling). Additionally, the first minute of feeding and handling was used for a short-term analysis of these parameters in 10-s intervals. Data from day 1–3 (period 1) and day 8–10 (period 2) were grouped into two separate periods. Our results revealed general differences between the coping styles during feeding, resting and handling, with proactive pigs showing higher HR compared to reactive pigs. This elevated HR was based on either lower vagal (resting) or elevated sympathetic activation (feeding, handling). The short-term analysis of the autonomic activation during feeding revealed a physiological anticipation reaction in proactive pigs in period 1, whereas reactive pigs showed this reaction only in period 2. Food intake was characterized by sympathetic arousal with concurrent vagal withdrawal, which was more pronounced in proactive pigs. In contrast, neither coping style resulted in an anticipation reaction to handling. Vagal activation increased in reactive pigs during handling, while proactive pigs showed an increase in sympathetically driven arousal in period 2. Our findings confirm significant context-related differences in the general autonomic reaction of pigs with different coping styles. Additionally, the two coping styles differ in their affective appraisal over the time course of the experiment, underlining the importance of taking individual differences into account when studying affect and emotion in humans and animals.

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“…In other words, different strains of mice may respond to stress with their own unique coping strategy, such that 129 have large HPA axis responses coupled with limited sympathomedullary activation, whereas C57 have large sympathomedullary responses coupled with more modest HPA axis activation. Prior work in outbred Wistar rats and an originally feral strain of rats, Wild Type Groningen, (both genetically diverse populations) identified two subtypes of stress coping responses among various individuals; one with a higher HPA axis response (corticosterone) and another with a higher sympathetic (noradrenaline) response (De Boer et al, 2017; de Boer et al, 1990; Koolhaas et al, 2010; 1999). It is intriguing to speculate that the current results utilizing the inbred 129 and C57 mouse lines illustrate an analogous concept, with the 129 similar to those rats with an HPA axis-dominant stress response and the C57 similar to those rats with a sympathomedullary-dominant stress response.…”

Section: Discussionmentioning

confidence: 99%

“…For example, during chronic stress, repeated and/or prolonged HPA axis activation can promote visceral adiposity and immunosuppression, suggesting that those with an HPA axis-dominant response may be preferentially predisposed for these stress-related disorders (De Boer et al, 2017; de Boer et al, 1990; Koolhaas et al, 2010; 1999). In contrast, repeated or prolonged sympathetic activation during chronic stress can promote hypertension, atherosclerosis and autoimmune disease, suggesting that those with a sympathomedullary-dominant response may be preferentially predisposed for these stress-related disorders (De Boer et al, 2017; de Boer et al, 1990; Koolhaas et al, 2010; 1999). It will be important for future work to focus on understanding the short- and long-term physiological impact of acute and chronic stress among individuals that rely primarily on HPA axis vs. sympathetic responses.…”

Section: Discussionmentioning

confidence: 99%

Apolipoprotein A-IV constrains HPA and behavioral stress responsivity in a strain-dependent manner

Packard

Zhang

Myers

et al. 2017

Psychoneuroendocrinology

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There is a critical gap in our knowledge of the mechanisms that govern interactions between daily life experiences (e.g., stress) and metabolic diseases, despite evidence that stress can have profound effects on cardiometabolic health. Apolipoprotein A-IV (apoA-IV) is a protein found in chylomicrons (lipoprotein particles that transport lipids throughout the body) where it participates in lipid handling and the regulation of peripheral metabolism. Moreover, apoA-IV is expressed in brain regions that regulate energy balance including the arcuate nucleus. Given that both peripheral and central metabolic processes are important modulators of hypothalamic-pituitary-adrenocortical (HPA) axis activity, the present work tests the hypothesis that apoA-IV activity affects stress responses. As emerging data suggests that apoA-IV actions can vary with background strain, we also explore the strain-dependence of apoA-IV stress regulation. These studies assess HPA axis, metabolic (hyperglycemia), and anxiety-related behavioral responses to psychogenic stress in control (wildtype) and apoA-IV-deficient (KO) mice on either the C57Bl/6J (C57) or 129x1/SvJ (129) background strain. The results indicate that apoA-IV KO increases post-stress corticosterone and anxiety-related behavior specifically in the 129 strain, and increases stress-induced hyperglycemia exclusively in the C57 strain. These data support the hypothesis that apoA-IV is a novel factor that limits stress reactivity in a manner that depends on genetic background. An improved understanding of the complex relationship among lipid homeostasis, stress sensitivity, and genetics is needed to optimize the development of personalized treatments for stress- and metabolism-related diseases.

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Untangling the neurobiology of coping styles in rodents: Towards neural mechanisms underlying individual differences in disease susceptibility

Cited by 130 publications

References 195 publications

Development of behavioural profile in the Northern common boa (Boa imperator): Repeatable independent traits or personality?

Development of behavioural profile in the Northern common boa (Boa imperator): Repeatable independent traits or personality?

Coping Style Modifies General and Affective Autonomic Reactions of Domestic Pigs in Different Behavioral Contexts

Apolipoprotein A-IV constrains HPA and behavioral stress responsivity in a strain-dependent manner

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