Untargeted metabolomics using liquid chromatography coupled with mass spectrometry for rapid discovery of metabolite biomarkers to reveal therapeutic effects of<i>Psoralea corylifolia</i>seeds against osteoporosis

Zhao, Fujiang; Zhang, Zhaobo; Ma, Ning; Teng, Xiaochun; Cai, Zhen-cheng; Liu, Ming-xi

doi:10.1039/c9ra07382e

Cited by 6 publications

(3 citation statements)

References 94 publications

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“…( 68 ) In a glucocorticoid‐induced osteoporosis rat model, cyanoamino acid metabolism was identified as a potential biomarker for osteoporosis using metabolomics. ( 69 ) This finding aligns with our results in which cyanoamino acid metabolism was higher in OP and OPN participants. However, it should be kept in mind that the results from previous studies came from a eukaryotic host or its tissues, rather than the microbiome and may be unrelated to the results seen from this study.…”

Section: Discussionsupporting

confidence: 92%

“…Interestingly, in a study of human osteoclasts, cyanoamino acid metabolism expression was downregulated in samples treated with bisphosphonates, drugs commonly used to treat osteoporosis by inhibiting bone resorption (68) . In a glucocorticoid-induced osteoporosis rat model, cyanoamino acid metabolism was identified as a potential biomarker for osteoporosis using metabolomics (69) . This finding aligns to our results in which cyanoamino acid metabolism was higher in OP and OPN participants.…”

Section: Discussionmentioning

confidence: 99%

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The Gut Microbiome Is Altered in Postmenopausal Women With Osteoporosis and Osteopenia

et al. 2021

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Osteoporosis and its precursor osteopenia are common metabolic bone diseases in postmenopausal women. A growing body of evidence suggests that the gut microbiota is involved in the regulation of bone metabolism; however, there are few studies examining how gut microbiomes in osteoporosis and osteopenia may differ from those in healthy individuals. The aim of this study was to characterize the diversity, composition, and functional gene potential of the gut microbiota of healthy, osteopenic, and osteoporotic women. Body composition, bone density, and fecal metagenomes were analyzed in 86 postmenopausal women. The women were classified as healthy, osteopenic, or osteoporotic based on T-scores. The taxonomic and functional gene compositions of the microbiome were analyzed using shotgun metagenomic sequencing. Both osteoporotic and osteopenic taxonomic compositions were found to be significantly different from healthy participants. Linear discriminant-analysis effect-size analyses identified that healthy participants had more unclassified Clostridia and methanogenic archaea (Methanobacteriaceae) than in both osteoporotic and osteopenic participants. Bacteroides was found to be more abundant in osteoporosis and osteopenia groups. Some KEGG pathways, including carbohydrate metabolism, biosynthesis of secondary metabolites, and cyanoamino acid metabolism, were found to be more abundant in both osteoporosis and osteopenia. These results show that osteoporosis and osteopenia alter the gut microbiome of postmenopausal women and identify potential microbial taxonomic and functional pathways that may be involved in this disease.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

The Gut Microbiome Is Altered in Postmenopausal Women With Osteoporosis and Osteopenia

et al. 2021

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“…Furthermore, ethanolic extract of P. corylifolia seeds significantly regulated 18 potential biomarkers related to the pathogenesis of osteoporosis in glucocorticoidinduced osteoporosis rats. These biomarkers were found to be involved in tryptophan, nicotinamide and arginine metabolism pathways [67]. The effect of P. corylifolia extract in the regulation of these metabolic pathways and their corresponding biomarkers provided evidence for its potential therapeutic use for osteoporosis treatment.…”

Section: Osteoporosis Managementmentioning

confidence: 95%

Pharmacologically Active Secondary Metabolites from Psoralea corylifolia

Ariantari

Ratnasantasyacitta

2022

J. Trop. Pharm. Chem.

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Psoralea corylifolia has gained much attention, particularly in the cosmetic industry for the past few years owing to promising pharmacological activities of its metabolites. Seeds of P. corylifolia are the main source of bakuchiol, a meroterpene compound that is extensively harnessed in numerous skincare products. Furanocoumarins, psoralen and isopsoralen are other metabolites mainly from P. corylifolia seeds and known for their antipsoriatic activity. Moreover, various studies have reported several classes of secondary metabolites from this plant possessing diverse biological activities. This article highlights recent updates on P. corylifolia phytoconstituents and their promising pharmacological activities based on scientific publications during the last 10 years (2011-2021). The literature search was carried out through scientific-based websites and databases such as Google Scholar, NCBI, and PubMed. This paper included sixty-three bioactive metabolites reported in the last 10 years, belonging to the group of flavonoids, meroterpenes, furanocoumarins, coumestans, steroid and phenolic compounds. These phytoconstituents displayed a broad range of bioactivities including anti-inflammatory, antibacterial, antidiabetic, controlling obesity, hepatoprotective and cytotoxicity. Keywords: Bakuchiol, pharmacological activities, Psoralea corylifolia, bioactive metabolites.

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Babchi

Azeem,

Javed,

AL-Huqail

2023

Essentials of Medicinal and Aromatic Crops

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Untargeted metabolomics using liquid chromatography coupled with mass spectrometry for rapid discovery of metabolite biomarkers to reveal therapeutic effects ofPsoralea corylifoliaseeds against osteoporosis

Abstract: Liquid chromatography coupled with mass spectrometry has been used as metabolomics profiling tool to discover and identify the metabolites in metabolic diseases.

Cited by 6 publications

References 94 publications

The Gut Microbiome Is Altered in Postmenopausal Women With Osteoporosis and Osteopenia

The Gut Microbiome Is Altered in Postmenopausal Women With Osteoporosis and Osteopenia

Pharmacologically Active Secondary Metabolites from Psoralea corylifolia

Babchi

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