Untersuchungen �ber die Bindung von Steroidhormonen an menschliche Schwangerschaftsproteine

Bohn, H.; Kranz, Th.

doi:10.1007/bf00668363

Cited by 36 publications

(3 citation statements)

References 14 publications

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“…Mit Sicherheit konnte damals lediglich eine Bindung des Oestriols festgestellt werden [4]. Die Steroidbindung wurde dureh Autoradiographie nach Anlagerung yon l~C-markierten Steroidhormonen an Immunpr~cipitate des Schwangerschaftsproteins naehgewiesen.…”

Section: Bindung Yon Steroidhormonenunclassified

Untersuchungen �ber das schwangerschafts-spezifische ?1-Glykoprotein (SP1)

Bohn

1974

Arch. Gynak.

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Studies on the Pregnancy-Specific ill" Glycoprotein (SP1)Summary. The pregnancy-specific fll-glyeoprotein (SP~) has a molecular weight of 90000=[=5000 as determined by electrophoresis in a sodium dodecylsulfate containing PAA gel. SP 1 was found to have an affinity for estriol, 17fl-estradiol and cortisol; at least these steroid hormones are bound to the immunopreeipitates of this protein. In cord blood serum SP 1 if any is present only in trace amounts (< 0,1 mg per 100 ml). Colostrum was found to contain small amounts of SP1, too. In sera from pregnant women the concentration of SP 1 reaches levels ranging from 5-20 mg per 100 ml. Post partum this protein disappears from the maternal blood with a half-life of 30-40 hours. Sera from pregnant monkeys contain a protein immunochemieally related to SP r The monkey protein (MSP1) like SP 1 is specific for gravidity, has the mobility of a ill-globulin and contains appreciable amounts of sialic acid. Rabbit antibodies to SP 1 when intravenously injected into pregnant monkeys induce abortion.

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Section: Bindung Yon Steroidhormonenunclassified

Untersuchungen �ber das schwangerschafts-spezifische ?1-Glykoprotein (SP1)

Bohn

1974

Arch. Gynak.

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“…Das Protein hat eine gewisse Affinitfit zu Steoidhormonen und zu Eisen (Bohn, H. et al, 1973;Lin, T.H. )ber die biologische Funktion des SP1 ist noch wenig bekannt.…”

Section: Schwanger Schaftsspezifisches ~ L-glyk Oprotein ( Sp1)unclassified

Schwangerschaftsspezifische und schwangerschaftsassoziierte Proteine in der Diagnostik und Verlaufskontrolle maligner Erkrankungen

Bauer

Bohn

1978

Klin Wochenschr

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Serum proteins are described the significance of which for pregnancy or for malignant growth is associated with their drastic increase or initial occurrence. In that immunological non-reaction (tolerance) against foreign antigen is inherent in both of the proceeding, and in that in vitro findings display immunosuppressive properties for the described serum proteins, a function within the scope of altered immunity can be conceived for these proteins. A dual role of the so called pregnancy-specific proteins and the pregnancy-associated proteins would be possible.The purpose of the neoplasma-derived serum proteins could be to block the efferent branch of the immune apparatus. They would occupy antigen determinants of the tumor cells and thereby inhibit the specific reaction mechanism of the effector cells as well as render the tumor invulnerable. The latter would closely resemble the earlier concept of a glycoprotein coat of the tumor cell. In this connection, the human Choriongonadotropin appears to be the best investigated and seems to confirm this model.The serum proteins, present in healthy individuals normally in almost indetectable amounts could, by contrast, acquire the function of blocking the afferent branch of the immune system. That is to say these proteins would be able to annul the recognition mechanism of immunologically competent lymphocytes, and to inhibit sensibilization. The electrophoretic mobility test of the pregnancy-associated ~2glycoprotein as well as the determination of el-fetoprotein receptors on T-lymphocytes are evidence for this concept.

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“…This pregnancy-associated \g=a\-macroglobulin(PAM) is not unique to pregnancy and its concentration has been determined in the serum of subjects with a variety of conditions (Stimson, 1973a(Stimson, , 1974. Treatment of both males and females with oestrogens results in elevations in the PAM serum level (Horne & co-authors, 1973; Berne, 1973;Stimson, 1974), but it is not involved in steroid transport (Stimson, 1973b;Bohn & Kranz, 1973;Von Schoultz, Stigbrand, Carstenson, Sodergard & Shanbhag, 1973). Recent investigations have shown that peripheral blood leucocytes are capable of synthesizing PAM but that lymphocytes are not the cell type responsible (Stimson & Blackstock, 1975).…”

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confidence: 99%

Variations in the Serum Concentration of a Human Pregnancy-Associated -Macroglobulin During Pregnancy and After Delivery

Stimson¹

1975

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Untersuchungen �ber die Bindung von Steroidhormonen an menschliche Schwangerschaftsproteine

Cited by 36 publications

References 14 publications

Untersuchungen �ber das schwangerschafts-spezifische ?1-Glykoprotein (SP1)

Untersuchungen �ber das schwangerschafts-spezifische ?1-Glykoprotein (SP1)

Schwangerschaftsspezifische und schwangerschaftsassoziierte Proteine in der Diagnostik und Verlaufskontrolle maligner Erkrankungen

Variations in the Serum Concentration of a Human Pregnancy-Associated -Macroglobulin During Pregnancy and After Delivery

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