Untersuchungen �ber die Stereotypien nach Amphetamin und Apomorphin sowie deren pharmakologische Beeinflussung

Menge, H.; Brand, U.

doi:10.1007/bf00403860

Cited by 18 publications

(3 citation statements)

References 25 publications

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“…The delayed gnawing response to morphine resembles similar observations with subcutaneous application of amphetamine to the rat (Menge & Brand, 1971). Here again an excitatory phase precedes stereotypy, the latter developing fully only 2 h after injection.…”

Section: Discussionsupporting

confidence: 76%

Compulsive Gnawing in Rats After Implantation of Drugs Into the Ventral Thalamus. A Contribution to the Mechanism of Morphine Action

Bergmann¹,

Chaimovitz²,

Pasternak³

et al. 1974

British J Pharmacology

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1Implantation of morphine into various parts of the corpus striatum of rats evokes only weak gnawing responses. 2 Deposition of apomorphine, morphine or methadone in the region of the nucleus ventralis thalami produces a biphasic response, i.e. general excitation, followed by a period of intense gnawing.3 The effect of both apomorphine and morphine is blocked by chlorpromazine, haloperidol and pimozide. However, pretreatment with ca-methyltyrosine methyl ester or a-methyldopa prevents only the gnawing response to morphine, but not to apomorphine. 4 Systemic nalorphine, morphine or pethidine suppress the gnawing response, evoked by thalamic implants of apomorphine or morphine. 5 Systemic amphetamine potentiates the effect of thalamic deposits of morphine. 6 Compulsive gnawing, following implantation of morphine into the ventral region of the thalamus, probably results from enhanced production and release of catecholamines.

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Section: Discussionsupporting

confidence: 76%

Compulsive Gnawing in Rats After Implantation of Drugs Into the Ventral Thalamus. A Contribution to the Mechanism of Morphine Action

Bergmann¹,

Chaimovitz²,

Pasternak³

et al. 1974

British J Pharmacology

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“…In this case, the potentiation of noradrenergic (NA) transmission by tricyclics appears to be responsible (Schelkunov 1980). However, other effects of high doses of apomorphine, including stereotyped behaviour (Menge and Brand 1971;Molander and Randrup 1976) and changes in blood pressure (Kadzielawa and Popielarski 1971), are enhanced by tricyclics. It seems unlikely that NA synapses are involved in these synergistic effects, since the potentiation of apomorphine stereotypy by tricyclics was unaffected by pharmacological treatments which abolish NA transmission (Molander and Randrup 1976).…”

Section: Discussionmentioning

confidence: 99%

Dopamine autoreceptors in the ventral tegmental area show subsensitivity following withdrawal from chronic antidepressant drug treatment

1986

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The suppression by apomorphine of food intake and eating time was used to assay the sensitivity of dopamine cell body autoreceptors during the course of treatment with DMI, amitriptyline and mianserin. Brief (2-4 days) DMI treatment enhanced the effects of apomorphine, administered systemically or centrally to DA cell body regions. During chronic DMI treatment (3-7 weeks) some evidence of autoreceptor subsensitivity was observed with systemic apomorphine, but not with central apomorphine. Responses to apomorphine applied systemically were reduced during withdrawal from chronic DMI, and responses to apomorphine applied to the ventral tegmental area were reduced during withdrawal from all three antidepressants. As evidence of DA autoreceptor subsensitivity was only observed reliably during withdrawal, this effect is unlikely to be of clinical importance.

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“…-Inhib. of stereotyped behaviour induced by d-amphetamine (7.0 mg/kg s.c.) was tested in male mice according to Menge and Brand (1971) -Catalepsy was tested in male rats (n =6/dose) according to the method described by Davidson et a1. (1983).…”

Section: C) Tests For Sedation Andalcohol Potentiationmentioning

confidence: 99%

1.2-Anellated 1.4-Benzodiazepine Derivatives - A New Class of Antipsychotics

Ruhland¹,

Liepmann²,

Muesch³

1985

Pharmacopsychiatry

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Untersuchungen �ber die Stereotypien nach Amphetamin und Apomorphin sowie deren pharmakologische Beeinflussung

Cited by 18 publications

References 25 publications

Compulsive Gnawing in Rats After Implantation of Drugs Into the Ventral Thalamus. A Contribution to the Mechanism of Morphine Action

Compulsive Gnawing in Rats After Implantation of Drugs Into the Ventral Thalamus. A Contribution to the Mechanism of Morphine Action

Dopamine autoreceptors in the ventral tegmental area show subsensitivity following withdrawal from chronic antidepressant drug treatment

1.2-Anellated 1.4-Benzodiazepine Derivatives - A New Class of Antipsychotics

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