Untersuchungen �ber die Wirkung von Di�t, Tolbutamid und Buformin sowie deren Kombination auf K�rpergewicht und verschiedene Stoffwechselgr��en bei Diabetikern

Kattermann, R; Appels, A.; K, Hubrich; Proschek, H; Söling, Hans‐Dieter; Creutzfeldt, W

doi:10.1007/bf00430098

Cited by 12 publications

(3 citation statements)

References 42 publications

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“…Others have suggested that enhanced NEFA supply to the liver is responsible for the increased ketogenesis [34], but in our patients there was no significant difference in plasma NEFA concentration during phenformin compared with metformin therapy, while ketonaemia was more marked with phenformin. The significant increase in glycerol concentrations seen with both biguanides is in agreement with results from perfusion of isolated rat [7] and guinea pig [5] livers.…”

Section: Discussioncontrasting

confidence: 85%

“…A significant increase in ketone body concentra-tions was found in our patients on biguanide therapy. This has received scant attention previously although isolated reports of increased ketonaemia have appeared [32,33] and a small increase in 3-hydroxybutyrate concentration was noted in patients taking buformin [34]. This could be explained by the more reduced state within the cell.…”

Section: Discussionmentioning

confidence: 99%

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Comparative effects of phenformin, metformin and glibenclamide on metabolic rhythms in maturity-onset diabetics

et al. 1977

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Twelve hour metabolic rhythms have been performed on six maturity-onset diabetic subjects during successive periods of therapy with phenformin, metformin, and glibenclamide. Moderate control of blood glucose concentration was achieved with phenformin and metformin, the lowest concentrations being found with glibenclamide. Mean blood lactate concentration was grossly elevated during phenformin therapy, moderately elevated with metformin and normal during glibenclamide treatment. Similar patterns were found for the lactate/pyruvate ratio, alanine, glycerol and ketone bodies. Serum triglyceride concentrations were significantly higher during phenformin treatment than with the other two regimes. Serum insulin concentration was higher on glibenclamide than with either biguanide. Most of these effects of the biguanides could be accounted for by an inhibitory effect on hepatic gluconeogenesis. It is concluded that the use of biguanides as hypoglycaemic agents in diabetes is associated with the production of multiple metabolic abnormalities.

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Section: Discussioncontrasting

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Comparative effects of phenformin, metformin and glibenclamide on metabolic rhythms in maturity-onset diabetics

et al. 1977

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“…The focussing of attention upon lactate metabolism has overshadowed a number of other metabolic effects produced by biguanides. Abnormally elevated concentrations of blood alanine, pyruvate, and total ketone bodies as well as the lactate/pyruvate ratio and 3-hydroxybutyrate/acetoacetate ratio occur during therapy with phenformin [11,12], metformin [11], and buformin [13] and it is clear that the abnormal blood lactate elevation is but one part of the metabolic derangement by which biguanides achieve a hypoglycaemic effect. These effects may, however, be more important overall than lactic acidosis.…”

mentioning

confidence: 99%