Untersuchungen �ber Relationen zwischen entz�ndlicher Infiltration, Zelltyp und Prognose beim malignen Melanom

Tritsch, H

doi:10.1007/bf00600171

Cited by 12 publications

(2 citation statements)

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“…Bei Metastasen fehlen L und Makrophagen fast regelmfil3ig [27]. An 253 M der Haut fanden Gartmann und Tritsch (1972) [67,187], dab bei einer starken zellig-entziindlichen Begleitreaktion die fSberlebenszeit signifikant verl/ingert war. An 253 M der Haut fanden Gartmann und Tritsch (1972) [67,187], dab bei einer starken zellig-entziindlichen Begleitreaktion die fSberlebenszeit signifikant verl/ingert war.…”

Section: Bedeutung Des Zellinfiltrates Beim Malignen Melanomunclassified

The immunology of malignant melanoma

Schieferstein

1975

Klin Wochenschr

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The Immunology of Malignant Melanoma. Summing'. A survey of the results of immunologic investigations in tumors concerning the malignant melanoma, is given -subdivided into the various in vitro and in vivo tests-, and emphasizing the viewpoints related to the clinic.Antibodies against various structures of melanoma cells can be traced optically by fluorescence in patients with melanoma but also in subjects with halo naevus. The motility of white blood cells of patients suffering from melanoma is inhibited by extracts of melanoma cells, but mostly only in localized tumors, as cytotoxic antibodies can be found only in such cases. The identification of cytotoxic lymphocytes and the stimulation of lymphocytes of patients through extracts of melanoma or PHA also depends essentially on the stage of the tumor. The serum factors-blocking the lymphocytes function-predominantly occur in the late stage of the tumor. The size of the lymphocytic stroma-reaction seems to be important regarding the prognosis. It is uncertain whether other serum factors play a decisive role in melanoma. Including unimportant restrictions, serogenetic and HL-A-investigations did not reveal obvious findings. Also is it uncertain in melanoma whether viruses play a part.By means of intracutaneous tests with unspecific and specific antigens, one tries to abtain in vivo information about the immunologic defence condition of the patient, thus one tries to ameliorate that condition with unspecific antigens or various preparations of melanoma cells. So far, all kinds of immunotherapy in melanoma resulted-if any-only in temporary successes. Key words': Malignant melanoma, tumor immunology, in vitro and in vivo tests, immunotherapy in melanoma, Zusammenjassung. Unter vorwiegend klinikbezogenen Gesichtspunkten werden die tumorimmunologischen Ergebnisse beim malignen Melanom, aufgeschlfisselt nach den verschiedenen in vitround in vivo-Tests zusammengefagt.Antik6rper gegen verschiedene Strukturen der Melanomzellen k6nnen bei Melanompatienten aber auch bei Personen mit Naevus Sutton fluorescenzoptisch nacbgewiesen werden. Weige Blutzellen yon Melanompatienten werden durch Melanomzellextrakte in ihrer Beweglichkeit gehemmt, meistens jedoch nur bei lokalisiertem Tumor, wie auch cytotoxische Antik6rper nur in solchen F/illen zu finden sin& Der Nachweis yon cytotoxischen Lymphocyten und die Stimutierbarkeit yon Pafienten-Lymphocyten durch Melanom-Extrakte oder PHA b/ingt ebenfatls wesentlich vom Tumor-Stadium ab. Die Lymphocytenfunktion blockierende Serumfaktoren treten vorwiegend im fortgeschrittenen Tumorstadium auf. Die Stfirke der lymphocytfiren Stromareaktion scheint prognostisch bedeutsam zu sein. Es ist ungewfl3, ob andere Serumfaktoren eine entscheidende Rolle bei Melanomen spMen. Serogenetische und HL-A-Untersuchungen baben mit geringen Einschrfinkungen zu keinen aufffilligen Befunden geffihrt. Ob Viren eine Rolle spielen, ist auch beim Melanora noch ungewiB.In vivo versucht man im Intrakutantest mit unspezifischen und spezifischen Antigenen AufschluB fib...

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Section: Bedeutung Des Zellinfiltrates Beim Malignen Melanomunclassified

The immunology of malignant melanoma

Schieferstein

1975

Klin Wochenschr

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“…Cellular infiltrate observed in the vicinity of different tumors has been investigated [Burg and Braun-Falco, 1972;Carr and Underwood, 1974] and evaluated as a favorable prognostic sign [Hamlin, 1968 ;Black and Lois, 1970 ;Gartmann and Tritsch, 1972;Tritsch, 1972] A reduced number of T lympho cytes and plasma cells was found in highly malignant cutaneous tumors [Viac et al, 1977]. In melanoma and other malignant tumors of the skin antitumoral local reactions can prevent tumor cell invasion only for a short period.…”

Section: Introductionmentioning

confidence: 99%

Electron Microscopic Investigation on the Local Cellular Reaction to Primary Malignant Melanoma

Szekeres¹,

Daróczy²

1981

Dermatology

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Five untreated primary malignant melanomas with relatively long duration have been investigated. Particular attention has been paid to the local cellular reaction observed in the intermediate zone lying between neoplastic and non-neoplastic tissue. Activated macrophages and histiocytes were seen as well as lymphocytes and lymphoid cells with cerebriforme nuclei. Also, Langerhans cells were found in this zone and a close contact between these cells and melanophages was observed. The importance of the peritumoral cellular reaction in the local defence to neoplasma is discussed.

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The prognostic significance of lymphocytic infiltration in malignant melanoma of the choroid

Lang

Davidorf

Baba

1977

Cancer

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Lymphocytic and plasmocytic infiltration surrounding a malignant tumor probably represents an immunologic response of the host directed against the neoplasm. It has been documented that lymphocytic infiltration has a favorable effect on prognosis in a num.ber of human tumor systems, including cutaneous melanoma. In the present study, 309 consecutive cases of choroidal melanoma were examined for cellular infiltration, and these data were correlated with other histologic parameters and with prognosis. An intense cellular infiltration was found in 15 tumors (4.9%) and a moderate infiltration in 37 (12.0%). Tumors with cellular infiltration were significantly larger and more vascula-rized than the remaining tumors, which may be related to the accessibility of the immune system to the tumor. There was a higher percentage of poorly differentiated tumors among the tumors with cellular infiltration. However, it does not appear that cellular infiltration favorably influences the prognosis of choroidal melanoma. The 5-year survival rates of patients with like cell types did not depend upon the degree of cellular infiltration demonstrated by the primary tumor. Although choroidal melanomas are capable of inciting an immune response, this response is apparently ineffective in preventing meta-static spread.

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Untersuchungen �ber Relationen zwischen entz�ndlicher Infiltration, Zelltyp und Prognose beim malignen Melanom

Cited by 12 publications

References 1 publication

The immunology of malignant melanoma

The immunology of malignant melanoma

Electron Microscopic Investigation on the Local Cellular Reaction to Primary Malignant Melanoma

The prognostic significance of lymphocytic infiltration in malignant melanoma of the choroid

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