Untersuchungen mit selektiven Abspaltungsreagenzien für ADPOC‐geschützte Aminosäuren und Peptide

Abstract

Selective reagents for the removal of the Adpoc group have been developed. For this purpose several peptides containing tryptophan and NE-Boc-lysine have been synthesized. Among several acidolytic reagents, 0.1 N HC1/TFEt/CHC13 (1:9: 1) and 50% HCOOH/TFEt/CHC13 (1 :9: 1) show high selectivity especially for the NE-tert-butyloxycarbonyl group of lysine. Cleavage rates are determined by HPLC and TLC.