Untersuchungen über den postmortalen ATP-Stoffwechsel der Magenmuskulatur der Ratte

Döring, G.; Patzer, Andreas; Forster, B.

doi:10.1007/bf00362626

Cited by 5 publications

(1 citation statement)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Der Verlauf der katabolen Veriinderungen ist mit denen vergleiehbar, Wie sie yon DSriug [5], Deuticke [4], Threffall [33] und Maeiwa [20] wKhrend Autolyse besehrieben wurden. An vergleiehbaren Versuehsmodellen mit Iseh~mie der Skeletmuskulatur liegen von Bollman [1], Imai [10] und Threlfall [33] Stoffwechseluntersuchungen vor.…”

Section: Energiestoffwechsel Unter Kontrollbedingungen Und Isch?imieunclassified

Die Restitution des Energiestoffwechsels der Skeletmuskulatur der Ratte nach langdauernder Ischämie

et al. 1973

View full text Add to dashboard Cite

Summary. In hind limbs of wistar-rats an ischemia was produced by tourniquets.Postischemic recovery was started by restoration of blood flow. The animals were held in ether-Inactin narcosis at constant room-temperature of 28°C. The shock, which oceured after tourniquet release was treated in a standardized manner. The extent of muscle-cell lesion was determined by changes in the tissue levels of energy-rich phosphates and metabolites of the glycolysis-cycle. Catabolic changes of metabolism during ischemia are characterized by a decrease in phosphocreatine, ATP, glycogen and an accumulation of lactate. Rate and extent of metabolic recovery were inverse proportional to the duration of ischemia. After ischemia of 2 and 3 hrs duration a rapid recovery in the metabolic pattern was measured. After ischemia of 4 hrs duration normalisation of the metabolic pattern only oecured, if the recovery period was extended to 6 weeks. After ischemia of 5 and 6 hrs duration no restitution was observed. Prom the biochemical data, obtained under the described experimental conditions, the ischemic tolerance of rat sceletal musculature concerning a rapid and longlasting recovery is exceeded after an ischemic period of 4 hrs. Key words: Extremity-ischemia --Muscular energy metabolism --Recirculation

show abstract