Untersuchungen über die Elastizität der Lunge und deren Bedeutung für die Zirkulation

Cloëtta, M.

doi:10.1007/bf01680906

Cited by 62 publications

(9 citation statements)

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“…This form of curve applies to isolated lungs of patients who had died from respiratory disease (Heynsius, 1892;Liebermeister, 1907; Romanoff, 1911), and also to the lungs in the intact thorax of living normal subjects (Rahn, Otis, Chadwick & Fenn, 1946;Stead, Fry & Ebert, 1952;Nims, Conner & Comroe, 1954, 1955Heaf & Prime, 1956;Butler, 1956Butler, , 1957. For other species, the data are more scanty: Cloetta (1913) found the relationship to be rectilinear for the intact lungs and thorax of the macaque, cat, and adult and puppy dog; but Saxton, Barnes & Sperling (1946) and Lawton & Joslin (1951) obtained sigmoid curves for the isolated lungs of rats inflated in a plethysmograph by reduction of the extrapulmonary pressure. In view of these reports it was not expected that the pressure-volume relationships in rabbit lungs would be other than simple: in fact they were found to be extremely complex, and quite different from any which have been reported for other species.…”

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The elastic pressure‐volume curves of the lungs and thorax of the living rabbit*

Bernstein¹

1957

The Journal of Physiology

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The usual methods of measuring the mechanical work of breathing, and of analysing it into components corresponding to the viscous resistance of the airways and to the elastic resistance of the expanding airways and alveoli, are based on the work of Bayliss & Robertson (1939). The lungs, in the intact thorax, are inflated with a sinusoidal air flow delivered by a piston pump driven in simple harmonic motion, and the intratracheal pressure and the displacement of the pump are recorded as co-variables. If the viscous pressure is linearly related to air flow and the elastic pressure is linearly related to distension of the lungs, the curve of intratracheal pressure against time will be a sine curve and the dynamic pressure-displacement figure will be an ellipse. The records, from experiments on cats, reproduced in Bayliss & Robertson's paper clearly are not true ellipses. They comment (p. 34 of their paper): 'The distortion from true elliptical form was always observed and it is clear that we are not dealing with a simple visco-elastic system.'Another method of recording was used by Dean & Visscher (1941) to measure the work of breathing in dogs. They ventilated their animals with a sinusoidal air flow, and recorded pump displacement and intratracheal pressure as concurrent curves against time. Some of their intratracheal pressure curves deviated from sine wave form in that the phase of falling pressure was of shorter duration than that of rising pressure. Bernstein (1953a, b) used a similar method of recording, to measure the work of breathing in rabbits, and obtained similarly non-sinusoidal intratracheal pressure curves. When Bayliss & Robertson's published tracings were analysed into their component curves, of intratracheal pressure and pump displacement against time, the pressure curve was found to be distorted from sine wave form in qualitatively the same way as the curves described above.

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confidence: 99%

The elastic pressure‐volume curves of the lungs and thorax of the living rabbit*

Bernstein¹

1957

The Journal of Physiology

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“…The vessels contained within these alveoli must be stretched correspondingly. Cloetta (12) showed that when a rubber tube is stretched by this amount the luminal volume of the tube increases by only 3%o. The present studies suggest that lung capillaries behave in the same way as the rubber tubes used by Cloetta so that stretching the alveolar surface has a negligible effect on pulmonary capillary blood volume.…”

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Effect of lung inflation on pulmonary diffusing capacity at rest and exercise.

Miller¹,

Johnson²

1966

J. Clin. Invest.

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Steady state measurements of the diffusing capacity of the lung are made at operational lung volume, whereas measurements by the breath-holding method are customarily made at full inspiration. The effect of lung inflation on diffusing capacity must be taken into account before the steady state and breath-holding methods can be validly compared.At rest the single breath diffusing capacity of the lung for CO (DLCO) increases as the lung is inflated, presumably due to expansion of the alveolar-capillary surface; the volume of blood in the pulmonary capillary bed does not increase (1-5). During exercise the diffusing capacity, measured at full inspiration, increases with pulmonary blood flow, and this increase is associated with expansion of the pulmonary capillary blood volume (1, 2, 6, 7). It is not known how changing the lung inflation affects the expansion of the pulmonary capillary surface and blood volume during exercise. pacity measurement. In young healthy adults the neon dilution method gives highly comparable values to the plethysmographic determination: for 11 young adults studied in our laboratory the mean total lung volume was 7.20 + 1.10 L at body temperature and pressure, saturated with water, (BTPS) by the neon method and 7.35 + 1.16 L by the plethysmograph. The slightly lower value for the neon method is largely explained by the fact that we had our subjects inspire 200 ml less than their vital capacities for the neon determinations.DLco, Qc, and pulmonary tissue volume were estimated at rest from the line best fitting the exponential fall of

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“…6) where ( , ) = p [ ]( , ) is the output of the play operator applied to .From the properties of the play operator in Proposition 3.1, namely (3.2) and (3.4), we can prove the Lipschitz continuity and the local monotonicity of the Preisach operator.Proposition3.4. Let be a function fulfilling Hypothesis 2.2.…”

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Periodic solutions of a hysteresis model for breathing

et al. 2020

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We propose to model the lungs as a viscoelastic deformable porous medium with a hysteretic pressure–volume relationship described by the Preisach operator. Breathing is represented as an isothermal time-periodic process with gas exchange between the interior and exterior of the body. The main result consists in proving the existence of a periodic solution under an arbitrary periodic forcing in suitable function spaces.

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Untersuchungen über die Elastizität der Lunge und deren Bedeutung für die Zirkulation

Cited by 62 publications

References 0 publications

The elastic pressure‐volume curves of the lungs and thorax of the living rabbit*

The elastic pressure‐volume curves of the lungs and thorax of the living rabbit*

Effect of lung inflation on pulmonary diffusing capacity at rest and exercise.

Periodic solutions of a hysteresis model for breathing

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