Untersuchungen über die pathologische Histologie, Pathogenese und postmortale Diagnose der seuchenhaften Gehirn-Rückenmarksentzündung (Bornaschen Krankheit) des Pferdes. Ein Beitrag zur vergleichenden Pathologie des Zentralnervensystems

Joest, E.

doi:10.1007/bf01654290

Cited by 22 publications

(32 citation statements)

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“…A rhinogenous infection has been suggested previously for spontaneous Boma disease in the horse (Joest and Degen 1911); the same suggestion has been made for other infections with neurotropic viruses (Johnson and Minas 1968). Indeed, i.n.…”

Section: Immunohistologymentioning

confidence: 90%

Axonal transport of Borna disease virus along olfactory pathways in spontaneously and experimentally infected rats

Morales

Herzog

Kompter

et al. 1988

Med Microbiol Immunol

127

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In this study it has been shown that infection of mother rats by Borna disease virus (BDV) from infected newborns led to a fatal disease. This differed both in clinical symptoms and in histological alterations from the form of the disease which occurred after intracerebral (i.c.) infection. Both parameters were, however, similar to those seen after experimental intranasal (i.n.) infection of adult rats. Detailed immunohistological studies showed clearly that after experimental i.n. infection, the infecting virus migrates intraaxonally from the neuroreceptors in the olfactory epithelium into the brain. It is therefore suggested that i.n. transmission is an important route of natural BDV infection.

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Section: Immunohistologymentioning

confidence: 90%

Axonal transport of Borna disease virus along olfactory pathways in spontaneously and experimentally infected rats

Morales

Herzog

Kompter

et al. 1988

Med Microbiol Immunol

127

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“…An incubation period of 2e3 months was estimated by experienced clinicians [58]. The way of transmission is unknown; a nasal transmission via olfactory bulb is most likely [6], but other ways of transmission cannot be ruled out. b Data from [11] (I ¼ a/(A Â 1/n): I, season index; a, number of BD cases per month; A, total number of BD cases during observation period, here 1983e1991; n, number of months.…”

Section: Vaccination and Epidemiological Implications Reflected By Thmentioning

confidence: 99%

“…Furthermore, it was shown that BDV infections may not only result in encephalitis but may also be associated with other kinds of diseases such as behavioral and movement disorders [5]. This development necessitates the definition of classical BD (cBD) of horses, sheep and a few other animal species within the endemic areas of central Europe as a clinical and pathomorphological entity [6,7], and differentiating it from findings associated with other kinds of symptoms or questionable diseases in other species and non-endemic areas. The latter forms still need final proof and should be regarded as non-classical and so far questionable forms.…”

Section: Introductionmentioning

confidence: 98%

Epidemiological pattern of classical Borna disease and regional genetic clustering of Borna disease viruses point towards the existence of to-date unknown endemic reservoir host populations

Dürrwald¹,

Kolodziejek

Muluneh³

et al. 2006

Microbes and Infection

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“…The disease owes its name after the town of Borna, in Saxony, where many horses from a cavalry regiment died during an epidemic in 1895. Early studies showed that BD could be transmitted by using brain homogenates from diseased horses, demonstrating the infectious nature of the disease [101,125,155,188]. Sensitivity to detergents, ultraviolet light, and organic solvents, together with filtration studies suggested that BD was caused by an enveloped virus, the Borna disease virus.…”

Section: Borna Disease Virusmentioning

confidence: 99%

Borna Disease Virus and the Brain

Gonzalez–Dunia

Sauder

Torre

1997

Brain Research Bulletin

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Viruses with the ability to establish persistent infection in the central nervous system (CNS) can induce progressive neurologic disorders associated with diverse pathological manifestations. Clinical, epidemiological, and virological evidence supports the hypothesis that viruses contribute to human mental diseases whose etiology remains elusive. Therefore, the investigation of the mechanisms whereby viruses persist in the CNS and disturb normal brain function represents an area of research relevant to clinical and basic neurosciences. Borna disease virus (BDV) causes CNS disease in several vertebrate species characterized by behavioral abnormalities. Based on its unique features, BDV represents the prototype of a new virus family. BDV provides an important model for the investigation of the mechanisms and consequences of viral persistence in the CNS. The BDV paradigm is amenable to study virus-cell interactions in the CNS that can lead to neurodevelopmental abnormalities, immune-mediated damage, as well as alterations in cell differentiated functions that affect brain homeostasis. Moreover, seroepidemiological data and recent molecular studies indicate that BDV is associated with certain neuropsychiatric diseases. The potential role of BDV and of other yet to be uncovered BDV-related viruses in human mental health provides additional impetus for the investigation of this novel neurotropic infectious agent.

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Untersuchungen über die pathologische Histologie, Pathogenese und postmortale Diagnose der seuchenhaften Gehirn-Rückenmarksentzündung (Bornaschen Krankheit) des Pferdes. Ein Beitrag zur vergleichenden Pathologie des Zentralnervensystems

Cited by 22 publications

References 0 publications

Axonal transport of Borna disease virus along olfactory pathways in spontaneously and experimentally infected rats

Axonal transport of Borna disease virus along olfactory pathways in spontaneously and experimentally infected rats

Epidemiological pattern of classical Borna disease and regional genetic clustering of Borna disease viruses point towards the existence of to-date unknown endemic reservoir host populations

Borna Disease Virus and the Brain

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