Untersuchungen über Phenthiazinderivate IV: Über die Synthese von 10-(Piperazinoacyl)-phenthiazinen

Die Addition der N-Alkyl-N'-(trimethyIsily1)carbodiimide 1 -7 an die Halogenketene 9-11 verlauft regioselektiv, wobei die in 3-Position halogenierten l-Alkyl-4-[(trimerhyIsilyl)imino]-2-azetidinone 12 -21 entstehen. Diese lassen sich leicht zu den halogenierten l-Alkyl-4-irnino-2-azetidinonen 22 -31 entsilylieren. -Diphenylacetylchlorid liefert rnit dem Carbodiimid 6 das Saureamid 32, und Bernsteinsaure-dichlorid gibt mit 4 und 5 die Saureamide 40 und 41. Aus Oxalsauredichlorid werden mit den Carbodiimiden 3 , 4 , 6 , 7 und 8 die ParabansAure-Derivate 33 -37 sowie aus Malonsaure-dichlorid mit 4 und 8 die Barbitursaure-Derivate 38 und 39 gebildet. P-Lactams via N-SilylcarbodiimidesThe addition of the N-alkyl-N'-(trirnethyIsilyl)carbodiimides 1 -7 to the haloketenes 9 -11 proceeds regioselectively to give the 3-halogenated l-alkyl-4-[(trimethylsilyl)imino]-2-azetidinones 12 -21. These can be easily desilylated to the halogenated l-alkyl-4-imino-2-azetidinones 22 -31. -Diphenylacetyl chloride gives with the carbodiimide 6 the carboxamide 32, and succinyl chloride yields with 4 and 5 the carboxamides 40 and 41. Oxalyl chloride forms with 3, 4, 6, 7, and 8 the parabanic acid derivatives 33 -37, and the reaction of malonyl chloride with 4 and 8 affords the barbituric acid derivatives 38 und 39.

show abstract

β‐Lactame über N‐Silylcarbodiimide

Birkofer

Lückenhaus

1984

Liebigs Ann. Chem.

View full text Add to dashboard Cite

show abstract

N-Homolupinanoyl and N-(ω-lupinylthio)alkanoyl derivatives of some tricyclic systems as ligands for muscarinic M1 and M2 receptor subtypes

Tasso¹,

Sparatore²,

Sparatore³

2003

Il Farmaco

View full text Add to dashboard Cite

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Untersuchungen über Phenthiazinderivate IV: Über die Synthese von 10-(Piperazinoacyl)-phenthiazinen

Cited by 2 publications

References 0 publications

β‐Lactame über N‐Silylcarbodiimide

β‐Lactame über N‐Silylcarbodiimide

N-Homolupinanoyl and N-(ω-lupinylthio)alkanoyl derivatives of some tricyclic systems as ligands for muscarinic M1 and M2 receptor subtypes

Contact Info

Product

Resources

About