Untersuchungen zum Ampicillin/Sulbactam-Spiegel im bestrahlten Unterkieferknochen bei Patienten mit oralen Plattenepithelkarzinomen

Heibel, Haley Danielle; Scheer, Martin; Reuther, T.; Hahn, M.; Trittler, Rainer; Egle, Hannes; Kümmerer, Klaus; Kübler, Alexander C.

doi:10.1007/s10006-005-0615-7

Cited by 6 publications

(6 citation statements)

References 14 publications

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“…In this study, the participants were not selected according to the presented disease and received only one dose of SAM (see Table 1 for the various diagnoses). We estimated the SAM concentration in PRF to be 150 µg/ml, which is in line with the plasma concentration reported in the literature [ 8 , 28 – 32 ]. Furthermore, the concentration in PRF after at least three infusions of SAM is comparable to our calculated SAM concentration [ 8 ].…”

Section: Discussionsupporting

confidence: 85%

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Investigation of three common centrifugation protocols for platelet-rich fibrin (PRF) as a bio-carrier for ampicillin/sulbactam: a prospective trial

Straub,

Utz,

Stapf

et al. 2023

Clin Oral Invest

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Objectives Different platelet-rich fibrin (PRF) protocols exist and are known to differ in resulting mechanical and bioactive properties. Centrifugation parameters may also influence drug release, in particular antibiotics, when using PRF as a bio-carrier. We thus evaluated three common protocols regarding effects on the bio-carrier properties. Materials and methods In a prospective trial comprising 33 patients, we compared different protocols for PRF as a bio-carrier for ampicillin/sulbactam (SAM). Blood samples were taken shortly after a single dose of ampicillin/sulbactam (2 g/1 g) was administered to patients intravenously. PRF was obtained by centrifugation and three protocols were used: protocol A (1300 rpm, 8 min, RCF-max = 208 g), B (2300 rpm, 12 min, RCF-max = 652 g), and C (1500 rpm, 14 min, RCF-max = 276 g). The antibacterial activity of PRF was investigated against five oral species in vitro, based on agar diffusion methodology. Results The study demonstrates that a single dose of SAM is sufficient to reach high concentrations in PRF in all protocols (150 µg/ml), which is comparable to the plasma SAM concentration. Antibacterial activity was inferred from the diameter of inhibition zones seen in agar diffusion tests using PRF discs. Protocol B resulted in the largest inhibition zones. One-way ANOVA revealed statistically improved results for protocol B for some bacteria. Conclusions The study provides valuable data on PRF antibiotic enrichment, notably SAM. A single dose of SAM is sufficient to reach clinically relevant concentrations in PRF. Clinical relevance These findings potentially extend the application of PRF, for example in patients with osteonecrosis of the jaw or in oral surgery (e.g., stick bone).

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Section: Discussionsupporting

confidence: 85%

“…Wildfeuer et al measured for example a SAM plasma concentration of 97/37.6 µg/ml 30 min after infusion. In another study, a SAM plasma concentration of 124.9/96.5 µg/ml was measured 20 min after infusion [ 32 ]. In our study, the mean time gap between infusion and blood sampling for PRF was approximately 17 min.…”

Section: Discussionmentioning

confidence: 99%

Investigation of three common centrifugation protocols for platelet-rich fibrin (PRF) as a bio-carrier for ampicillin/sulbactam: a prospective trial

Straub,

Utz,

Stapf

et al. 2023

Clin Oral Invest

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“…Evaluating the concentration of ampicillin in irradiated jawbone, Heibel et al [ 20 ] found a concentration of ampicillin/sulbactam of 5.51/1.21 µg/g after two doses of 3 g of ampicillin/sulbactam in bone specimens obtained at 110–430 min after infusion of the first dose of ampicillin/sulbactam. In line with our results, this concentration was much lower than the ampicillin/sulbactam concentration reported for healthy bone [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

“…In all of these studies, the authors concluded that a single intravenous dose of the antibiotic agent investigated could provide adequate antimicrobial prophylaxis [ 16 , 17 , 18 , 19 ]. Evaluating the concentration of intravenously administered ampicillin/sulbactam in irradiated jawbone, Heibel et al [ 20 ] found concentrations 3–4 times lower than in healthy, non-irradiated bone. However, these concentrations were still above the minimum inhibitory concentration (MIC) of frequent oral pathogens [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

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Concentration of Penicillin G in Jawbone Affected by Antiresorptive Agent-Related Osteonecrosis Following a Single Preoperative Dose

et al. 2020

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The aim of this study was to evaluate the concentration of penicillin G in bone affected by antiresorptive agent-related osteonecrosis of the jaw (ARONJ) following a single preoperative dose of 10 million international units (6000 mg). ARONJ is a major concern in patients administered antiresorptive agents for conditions associated with pathologically increased bone resorption. Antibiotic therapy is a key component of most treatment approaches for ARONJ and penicillin based regimens, providing a cost effective therapy option with a favorable side effect profile, are administered most frequently. In this study, high performance liquid chromatography with tandem mass spectrometry (HPLC-MS/MS) was applied to evaluate penicillin G concentration in serum and bone samples of 19 patients suffering from ARONJ and undergoing surgical treatment under perioperative intravenous (IV) antibiotic therapy. Penicillin G bone concentrations were above the limit of detection (0.1 μg/g bone tissue) in 16 out of 19 samples, with a median concentration of 2.7 μg/g (range 0.1–8.8 μg/g). Penicillin G concentrations in intraoperative serum samples were above the limit of detection in all serum samples, with a median concentration of 116 μg/mL (range 1–232 μg/mL). Thus, considering bacteria frequently found in ARONJ lesions, penicillin G at levels providing adequate antimicrobial activity was detected in the serum and 16 out of 19 osteonecrotic lesions of patients suffering from ARONJ.

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Osteoradionecrosis and Antiresorptive Drug-Related Osteonecrosis of the Jaws

Al‐Nawas

Voss

2019

Craniomaxillofacial Reconstructive and Corrective Bone Surgery

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Untersuchungen zum Ampicillin/Sulbactam-Spiegel im bestrahlten Unterkieferknochen bei Patienten mit oralen Plattenepithelkarzinomen

Abstract: The results of this study suggest, that Unacid is an effective antibiotic in the prophylaxis of ORN in irradiated patients with head and neck tumors.

Cited by 6 publications

References 14 publications

Investigation of three common centrifugation protocols for platelet-rich fibrin (PRF) as a bio-carrier for ampicillin/sulbactam: a prospective trial

Investigation of three common centrifugation protocols for platelet-rich fibrin (PRF) as a bio-carrier for ampicillin/sulbactam: a prospective trial

Concentration of Penicillin G in Jawbone Affected by Antiresorptive Agent-Related Osteonecrosis Following a Single Preoperative Dose

Osteoradionecrosis and Antiresorptive Drug-Related Osteonecrosis of the Jaws

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