Untersuchungen zur circadianen Rhythmik der Glucosetoleranz

Grabner, W; Matzkies, F.; Prestele, H; Rose, Agostino Maria De; Daniel, Uduak; Phillip, J; Fischer, Konrad

doi:10.1007/bf01614859

Cited by 7 publications

(2 citation statements)

References 19 publications

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“…(However, fasting glucose is usually lower in the afternoon and evening than in the morning [51, 63]. ) The size of the diurnal variation in glucose tolerance is strikingly large: adults with normal glucose tolerance in the morning are metabolically equivalent to being prediabetic in the evening [33, 36, 46]. More recently, we reported that oral glucose tolerance in prediabetic adults was 40 mg/dl higher at 19:00 h than at 7:00 h, making prediabetic adults metabolically equivalent to early-stage diabetics at dinnertime [63].…”

Section: Circadian and Diurnal Rhythms In Metabolismmentioning

confidence: 99%

Circadian regulation of glucose, lipid, and energy metabolism in humans

2018

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The circadian system orchestrates metabolism in daily 24-hour cycles. Such rhythms organize metabolism by temporally separating opposing metabolic processes and by anticipating recurring feeding-fasting cycles to increase metabolic efficiency. Although animal studies demonstrate that the circadian system plays a pervasive role in regulating metabolism, it is unclear how, and to what degree, circadian research in rodents translates into humans. Here, we review evidence that the circadian system regulates glucose, lipid, and energy metabolism in humans. Using a range of experimental protocols, studies in humans report circadian rhythms in glucose, insulin, glucose tolerance, lipid levels, energy expenditure, and appetite. Several of these rhythms peak in the biological morning or around noon, implicating earlier in the daytime is optimal for food intake. Importantly, disruptions in these rhythms impair metabolism and influence the pathogenesis of metabolic diseases. We therefore also review evidence that circadian misalignment induced by mistimed light exposure, sleep, or food intake adversely affects metabolic health in humans. These interconnections among the circadian system, metabolism, and behavior underscore the importance of chronobiology for preventing and treating type 2 diabetes, obesity, and hyperlipidemia.

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Section: Circadian and Diurnal Rhythms In Metabolismmentioning

confidence: 99%

Circadian regulation of glucose, lipid, and energy metabolism in humans

2018

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“…These include secretory processes in the gastrointestinal tract (13, 21J and especially the secretion of the endocrine organs (8,25).…”

Section: Effect Of Time Of Daymentioning

confidence: 99%

Circadian rhythm of colonic motility in the cat

Wienbeck

Kreuzpaintner²

1976

Res. Exp. Med.

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Since circadian patterns of colonic motility are largely unknown the electrical activity of the colon musculature was recorded in 6 unanesthetized cats during day and night. All parts of the colon exhibited 6 patterns of electrical activity: spikes, oscillations, omnipresent regular slow waves, and three composite patterns, i.e. a minute-rhythmic activity, activity complexes of 1 to 18 minute duration and a nyctohemeral pattern. The circadian rhythm was different between the proximal and distal colon resulting in activity gradients. These were directed in an aborad direction from 7 to 9 a.m. and from 9 p.m. to midnight. Most of the defecations of the 6 cats occured in the late evening until 1 a.m. Spike activity of the distal colon predominated from 3 to 4 a.m. and from 11 a.m. to 5 p.m. It is concluded that a circadian rhythm exists in the motility of the cat colon. Differences in the activity between the proximal and the distal colon and resulting activity gradients may offer an explanation for the influences of the time of day on the timing of defecations.

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Diabetes mellitus und Schwangerschaft

Weiss¹,

Hofmann²

1985

Spezielle Gynäkologie Und Geburtshilfe

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Untersuchungen zur circadianen Rhythmik der Glucosetoleranz

Cited by 7 publications

References 19 publications

Circadian regulation of glucose, lipid, and energy metabolism in humans

Circadian regulation of glucose, lipid, and energy metabolism in humans

Circadian rhythm of colonic motility in the cat

Diabetes mellitus und Schwangerschaft

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