Untersuchungen zur Entwicklung einer Makro- und Mikroangiopathie beim streptozotozindiabetischen Miniaturschwein

Oberhofer, H.; Marshall, M.

doi:10.1007/978-3-642-85454-5_204

Cited by 1 publication

(2 citation statements)

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“…Furthermore, the close correlation between increasing thickening of the basement membrane of muscular capillaries and the duration of the diabetes found in our study supports a direct, i.e., causal, connection and hence the "metabolic theory" of the development of diabetic microangiopathy [19].…”

Section: Development Of Angiopathysupporting

confidence: 62%

“…In view of its relatively specific and dosedependent beta-toxicity and its ability to produce dose-dependently a diabetes of varying grades of severity and also a metabolic state comparable to latent diabetes [8,11], streptozotocin appeared to be particularly suitable and interesting for inducing diabetes. Having found the optimal method for diabetes induction [11], we could initiate investigations concerning the development of diabetic angiopathies [19].…”

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confidence: 99%

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Early micro- and macro-angiopathy in the streptozotocin diabetic minipig

Marshall¹,

Oberhofer²,

Staubesand

1980

Res. Exp. Med.

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Streptozotocin diabetes in the minipig constitutes an outstanding model for the study of diabetic angiopathies. Changes which are classified as macroangiopathy are evident after 6 months, while the first changes indicative of microangiopathy appear already after about 18 months. The degree of pronouncement of the microangiopathy depends on the duration and severity of the induced diabetes. These results constitute a cogent argument in favour of the "metabolic theory" of the development of diabetic microangiopathy.

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Section: Development Of Angiopathysupporting

confidence: 62%

mentioning

confidence: 99%