Untersuchungen zur Frage einer Aminosäuren-Imbalance unter den Bedingungen einer experimentellen Hypertyrosinämie bei der Ratte

Abstract

Tlie question of amino acid imbalance under the conditions of experimental hypertyrosinaemia in the ratC] L-leucine, the animals were killed, and the concentration of free amino acids and the utilization of the labelled pool for protein synthesis were determined in the serum, brain, liver, lung, spleen and kidneys. In the serum, brain and liver, the concentrations of free amino acids were determined by column Chromatography. Owing to a rapid degradation to metabolic end products, the high dose of tyiosine did not result in a hypertyrosinaemia, i. e., there was neither an inhibition of the transport of essential amino acids into the cells, nor an interference in protein synthesis. The relatively high tissue concentration of tyrosine metabolites had no recognizable negative effect on tissue metabolism.