Untersuchungen zur mammatumorhemmenden Wirkung von cis‐Bis(glycylglycinethylester)platin(II)chlorid

Abstract

Studies on the Mammuy tom^ Inhibiting Effect of ds.Dkhlorobis(glycyIglycinethyl#rter)pla~nm(ll)In vivo, cis-dichlorodiammineplatinurn(I1) (1) and cis-dichlorobis(g1ycylglycinethylester)platinum(I1) (2) inhibit the DMBA-induced hormone dependent mammary carcinoma of the SD rat. In vitro, a marked effect on the DNA synthesis of mammary tumor cells and an inhibition of the 'H-E, receptor interaction can be. demonstrated. A binding to DNA and an inhibition of the proliferation stimulating effect of endogenous estrogens by blocking the hormone receptors are discussed as modes of action.

Optimization of cisplatin for the treatment of hormone dependent tumoral diseases

“…[31][32][33][34][35][36][37][38][39] and [61] cited therein). Presumably this effect contributes as well to the anti-breast cancer activity of ER-agonistic or ER-antagonistic Pt-complexes.…”

“…It was assumed that the complexes were enriched in tumor cells due to an increased uptake of amino acids, peptides and proteins by the latter. The pharmacology of these compounds was thoroughly studied [36][37][38][39][40][41][42].…”