Unusual anatomic location of a primary intracranial yolk sac tumor

Al-Masri, Anwar; Khasawneh, Nidal; Aladily, Tariq N.

doi:10.4103/0256-4947.76410

Cited by 7 publications

(1 citation statement)

References 7 publications

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“…Extra-gonadal GCTs represent 1% - 5% of all germ cell tumors [ 1 ]. Extra-gonadal GCTs usually arise from midline structures, the commonest sites being the retroperitoneum, mediastinum, sacrococcygeal region, pineal gland [ 2 , 3 ]. In the cases in the literature, germ cell cancers originated from gastrointestinal system (GIS) are rarely presented in the stomach, esophagus, rectum colon and liver [ 4 - 6 ].…”

Section: Introductionmentioning

confidence: 99%

Germ Cell Tumor Located in Gastrointestinal System: A Report of Two Cases

et al. 2012

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Germ cell tumors (GCTs) occur generally in the testes or ovaries. Extra-gonadal location of GCTs is very rare .Extra-gonadal GCTs usually arise from midline structures, the commonest sites being the retroperitoneal and mediastinum. Gastrointestinal germ cell tumors are very uncommon. The etiology, prognosis and clinical course of gastrointestinal GCTs are not well understood yet. Weherein present two GCTs cases who referred with gastrointestinal bleeding and obstruction these tumors originated from retroperitoneal site. In the light of the literature, the clinical and pathological findings of the cases are presented. Prominent features of our cases were being located in the gastrointestinal system, being at young ages, presenting with gastrointestinal bleeding and good outcome.

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Section: Introductionmentioning

confidence: 99%

Germ Cell Tumor Located in Gastrointestinal System: A Report of Two Cases

et al. 2012

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Primary intracranial pure endodermal sinus tumor: A retrospective series of 6 cases in a single center and a systematic review of overall survival

et al. 2021

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Multidisciplinary treatment of primary intracranial yolk sac tumor

Yue

Cao

et al. 2021

Medicine

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Rationale: Intracranial yolk sac tumors (YSTs) are rare malignancies with limited treatment options and a dismal prognosis. They are usually managed with surgical resection and chemoradiotherapy. Patient concerns: Here, we report a patient with primary YST in the pineal region who achieved long term survival. Despite undergoing treatment, he experienced several recurrences over a 15-year period. Diagnosis: Brain magnetic resonance imaging (MRI) demonstrated the presence of space-occupying lesions in the pineal region and the medial tail of the left lateral ventricle. The tumors were excised, and the histological diagnosis suggested an intracranial YST. Interventions: The patient achieved long term survival after combined modality therapy including surgery, stereotactic radiosurgery (SRS)/intensity modulated radiation therapy (IMRT), chemotherapy, and targeted therapy. Outcomes: The disease remained stable. However, the patient gave up treatment and passed away in October 2020, with a total survival of about 15 years. Lessons: To the best of our knowledge, this patient with intracranial YST had received a longer survival compared with other published reports. We summarize previously published reports of intracranial YST and discuss the importance of multidisciplinary treatment. SRS may have a role, as a focal boost to residual tumor after resection or in case of recurrence after conventional radiotherapy, in the multimodality management of intracranial YSTs.

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Unusual anatomic location of a primary intracranial yolk sac tumor

Cited by 7 publications

References 7 publications

Germ Cell Tumor Located in Gastrointestinal System: A Report of Two Cases

Germ Cell Tumor Located in Gastrointestinal System: A Report of Two Cases

Primary intracranial pure endodermal sinus tumor: A retrospective series of 6 cases in a single center and a systematic review of overall survival

Multidisciplinary treatment of primary intracranial yolk sac tumor

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