Unusual association of two cases of acute myeloblastic leukaemia and possible Sjogren’s syndrome and review of literature

Brault, C.; Gourguechon, C.; Chehimi, Mohamad; Parcelier, Anne; Marolleau, Jean‐Pierre

doi:10.7243/2052-434x-5-2

Cited by 1 publication

(2 citation statements)

References 16 publications

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Section: Discussionmentioning

confidence: 99%

“…10 One case report describes unilateral eyelid swelling, proptosis and diplopia as initial manifestation of AML in a 17-year-old man. 11 There are two described cases of Sjogren's syndrome associated with AML 12 and one case of uveitis and keratoconjunctivitis sicca associated with human T-cell lymphotropic virus type 1 (HTLV-1) T-cell leukaemia/ lymphoma. 13 The main take-home message of this case is that nonresolving DES may be a manifestation of more serious conditions and should be investigated in case of persistent symptoms.…”

Section: Discussionmentioning

confidence: 99%

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A case of severe dry eye disease with corneal melting as presenting complaint of acute myeloid leukaemia

Pchejetski

Alshaker

Babović

et al. 2021

SAGE Open Medical Case Reports

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Dry eye syndrome is a common multifactorial disorder of the tear film and ocular surface. In rare cases, it may be caused by systemic diseases. Corneal melting is a complication of dry eye syndrome and is a potentially blinding condition. Here we report a case of a 67-year-old patient who attended her general practitioner for a year complaining of persistent dry eyes. Ophthalmological assessment showed severe dry eye syndrome with cornea melting in left eye. Blood test revealed anaemia and thrombocytopenia with circulating blasts. Bone marrow biopsy showed 15% myeloblasts with monosomy 7, compatible with acute myeloid leukaemia. Patient was started on intensive chemotherapy regime and was a candidate for allogenic bone marrow transplant. To our knowledge, this is the first case report demonstrating dry eye syndrome with sterile corneal melting as the possible presenting complaints of acute myeloid leukaemia. This case will serve as a useful reminder to general practitioners and accident and emergency doctors about the current guidelines regarding referral of persistently symptomatic patients with dry eye syndrome for further investigation in secondary care.

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