Unusual Bacterial Infections and Colorectal Carcinoma— Streptococcus bovis and Clostridium septicum : Report of Three Cases

Wentling, Grettel K.; Metzger, Philip P.; Dozois, Eric J.; Chua, Heidi K; Krishna, Murli

doi:10.1007/s10350-006-0576-4

Cited by 42 publications

(24 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, differently from drivers, which are always pro-carcinogenic, passenger bacteria can be of either pro-carcinogenic or protective nature, depending on the microorganism. While in some cases the carcinogenic tissue has been shown to be selectively colonized by opportunistic pathogens, such as Fusobacterium [78,83,84] , Streptococcus gallolyticus [98] and Clostridium septicum [99] , which can be involved in CRC progression, in other circumstances the tumor sites were enriched in passenger bacteria belonging to well-known mutualistic microbiota components, as Corynebacteriaceae, Roseburia and Faecalibacterium, suggesting a possible protective role for these microorganisms as CRC quencher [78] .…”

Section: Bacterial Driver-passenger Modelmentioning

confidence: 98%

Inflammation and colorectal cancer, when microbiota-host mutualism breaks

Candela

Turroni

Biagi

et al. 2014

WJG

171

138

View full text Add to dashboard Cite

Structural changes in the gut microbial community have been shown to accompany the progressive development of colorectal cancer. In this review we discuss recent hypotheses on the mechanisms involved in the bacteria-mediated carcinogenesis, as well as the triggering factors favoring the shift of the gut microbiota from a mutualistic to a pro-carcinogenic configuration. The possible role of inflammation, bacterial toxins and toxic microbiota metabolites in colorectal cancer onset is specifically discussed. On the other hand, the strategic role of inflammation as the keystone factor in driving microbiota to become carcinogenic is suggested. As a common outcome of different environmental and endogenous triggers, such as diet, aging, pathogen infection or genetic predisposition, inflammation can compromise the microbiota-host mutualism, forcing the increase of pathobionts at the expense of health-promoting groups, and allowing the microbiota to acquire an overall pro-inflammatory configuration. Consolidating inflammation in the gut, and favoring the bloom of toxigenic bacterial drivers, these changes in the gut microbial ecosystem have been suggested as pivotal in promoting carcinogenesis. In this context, it will become of primary importance to implement dietary or probiotics-based interventions aimed at preserving the microbiota-host mutualism along aging, counteracting deviations that favor a pro-carcinogenic microbiota asset.

show abstract

Section: Bacterial Driver-passenger Modelmentioning

confidence: 98%

Inflammation and colorectal cancer, when microbiota-host mutualism breaks

Candela

Turroni

Biagi

et al. 2014

WJG

171

138

View full text Add to dashboard Cite

show abstract

“…This association has led to a strong indication for gastrointestinal investigation and endoscopic follow-up in the case of S. gallolyticus infections (66). The association of S. gallolyticus infection with colon cancer is a major but still unsolved issue.…”

mentioning

confidence: 99%

Genome Sequence ofStreptococcus gallolyticus: Insights into Its Adaptation to the Bovine Rumen and Its Ability To Cause Endocarditis

et al. 2010

View full text Add to dashboard Cite

Streptococcus gallolyticus (formerly known as Streptococcus bovis biotype I) is an increasing cause of endocarditis among streptococci and frequently associated with colon cancer. S. gallolyticus is part of the rumen flora but also a cause of disease in ruminants as well as in birds. Here we report the complete nucleotide sequence of strain UCN34, responsible for endocarditis in a patient also suffering from colon cancer. Analysis of the 2,239 proteins encoded by its 2,350-kb-long genome revealed unique features among streptococci, probably related to its adaptation to the rumen environment and its capacity to cause endocarditis. S. gallolyticus has the capacity to use a broad range of carbohydrates of plant origin, in particular to degrade polysaccharides derived from the plant cell wall. Its genome encodes a large repertoire of transporters and catalytic activities, like tannase, phenolic compounds decarboxylase, and bile salt hydrolase, that should contribute to the detoxification of the gut environment. Furthermore, S. gallolyticus synthesizes all 20 amino acids and more vitamins than any other sequenced Streptococcus species. Many of the genes encoding these specific functions were likely acquired by lateral gene transfer from other bacterial species present in the rumen. The surface properties of strain UCN34 may also contribute to its virulence. A polysaccharide capsule might be implicated in resistance to innate immunity defenses, and glucan mucopolysaccharides, three types of pili, and collagen binding proteins may play a role in adhesion to tissues in the course of endocarditis.

show abstract

“…Th e infection might predate malignant tumors by several years. Hence, follow-up evaluation might be important in patients who survive (6). Early treatment is vital for this rapidly spreading infection, Fatal Clostridium septicum infection in a patient with a hematological malignancy Ragesh Panikkath, MD, DNB, DM, Venu Konala, MD, Deepa Panikkath, MD, Elvira Umyarova, MD, and Fred Hardwicke, MD with a mortality rate close to 100% if not treated within 12 to 24 hours (7).…”

Section: Discussionmentioning

confidence: 99%