Unusual calvarial tumour-oncogenic osteomalacia

Mani, Manoranjitha Kumari; Panigrahi, Manas

doi:10.3109/02688697.2016.1161165

Cited by 3 publications

(6 citation statements)

References 5 publications

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“…C-terminal assay was used in all cases [ 8 – 12 ] except that reported here in which iFGF23 was measured. As in our case, the tumor was detected in other six patients by functional imaging [ 7 – 12 ]. The suspicious lesion was confirmed by MRI in our case and in other five patients [ 7 – 10 ] and by CT scan in another one [ 11 ].…”

Section: Literature Reviewsupporting

confidence: 71%

“…As in our case, the tumor was detected in other six patients by functional imaging [ 7 – 12 ]. The suspicious lesion was confirmed by MRI in our case and in other five patients [ 7 – 10 ] and by CT scan in another one [ 11 ]. Interestingly, the tumor involved invariably the left side of the occipital bone.…”

Section: Literature Reviewsupporting

confidence: 71%

“…In three patients [ 9 – 11 ], a postoperative drop of serum FGF23 was documented after surgery. The complete surgical removal of the tumor was obtained in three patients [ 7 , 9 , 10 ], with at least 3 months of follow-up for the two of them. Surgery was unsuccessful in one case [ 8 ].…”

Section: Literature Reviewmentioning

confidence: 99%

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Occipital bone and tumor-induced osteomalacia: a rare tumor site for an uncommon paraneoplastic syndrome

et al. 2023

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Introduction Tumor-induced osteomalacia (TIO) is an uncommon paraneoplastic syndrome due to the overproduction of fibroblast growth factor 23 (FGF23). It is predominantly caused by mesenchymal tumors and cured upon their complete removal. Non-surgical treatment is an alternative option but limited to specific clinical conditions. Methods We report a challenging case of TIO caused by a tumor involving the occipital bone. We also performed a literature review of TIO caused by tumors localized at this site, focusing on clinical findings, treatment, and outcomes. Results The patient, a 62-year-old male, presented with a long-lasting history of progressive weakness. Biochemical evaluation revealed severe hypophosphatemia due to low renal tubular reabsorption of phosphate with raised intact FGF23 values. A 68 Ga-DOTATATE PET/TC imaging showed a suspicious lesion located in the left occipital bone that MRI and selective venous catheterization confirmed to be the cause of TIO. Stereotactic gamma knife radiosurgery was carried out, but unfortunately, the patient died of acute respiratory failure. To date, only seven additional cases of TIO have been associated to tumors located in the occipital bone. Furthermore, the tumor involved the left side of the occipital bone in all these patients. Conclusion The occipital region is a difficult area to access so a multidisciplinary approach for their treatment is required. If anatomical differences could be the basis for the predilection of the left side of the occipital bone, it remains to be clarified.

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Section: Literature Reviewsupporting

confidence: 71%

Section: Literature Reviewsupporting

confidence: 71%

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Occipital bone and tumor-induced osteomalacia: a rare tumor site for an uncommon paraneoplastic syndrome

et al. 2023

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“…Here we present a detailed review of published English literature for TIO cases involving head and neck region ( n = 163) (5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, …”

Section: Discussionmentioning

confidence: 99%

Tumor induced osteomalacia in head and neck region: single center experience and systematic review

Shah

Lila

Jadhav

et al. 2019

Endocrine Connections

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Tumor-induced osteomalacia in the head and neck region remains a challenging diagnosis to manage. Literature pertaining to management and outcome details remains sparse. We describe two cohorts: cohort 1 included seven patients from a single center in Western India with tumors located in paranasal sinuses (n = 3), intracranial (n = 2) and maxilla (n = 2). The unique features from our series is the management of persistent disease with radiation therapy (n = 2) and peptide receptor radionuclide therapy (PRRT) (n = 1). Cohort two has 163 patients identified from 109 publications for systematic review. Paranasal sinuses, mandible, intracranial disease, maxilla and oral cavity, in descending order, are reportedly common tumor sites. Within this cohort, mean age was 46 ± 14 years at presentation with 44.1% having local symptoms. Duration of symptoms varied from 1 to 240 months. Pre-surgery mean serum phosphorus was 1.4 ± 0.4 mg/dL and median FGF-23 levels were 3.6 (IQR:1.8–6.8) times of normal upper limit of normal. Majority (97.5%) were managed primarily with surgical excision; however, primary radiotherapy (n = 2) and surgery combined with radiotherapy (n = 2) were also reported. Twenty patients had persistent disease while nine patients had recurrence, more commonly noted with intracranial and oral cavity tumors. Surgery was the most common second mode of treatment employed succeeded by radiotherapy. Four patients had metastatic disease. The most common histopathological diagnosis reported is PMT mixed connective tissue, while the newer terminology ‘PMT mixed epithelial and connective tissue type’ has been described in 15 patients.

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“…3,4 Patients can receive relief from symptoms significantly after surgical operation once the tumour is spotted correctly, and most patients can be cured accordingly. 5 TIO lesions can be found in bone, soft tissue and skin, and there are few cases of TIO combined with thyroid tumours, therefore this case of TIO combined with thyroid papillary carcinoma is to be described and the experience in diagnosis and treatment of TIO patients with thyroid tumours is shared in this report.…”

mentioning

confidence: 97%

Left maxillary sinus tumour‐induced hypophosphataemic osteomalacia and combined with thyroid papillary carcinoma: a case report and literature review

Dong

Liu

et al. 2020

Internal Medicine Journal

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Tumour-induced osteomalacia (TIO) is a rare disease characterised by hypophosphataemia and clinical symptoms of osteomalacia. Herein we report the case of a 29-year-old man who was admitted to hospital with progressive bone pain and was diagnosed with TIO caused by maxillary sinus tumours. In the preoperative evaluation, it was found that the patient had thyroid malignant tumours at the same time. Two operations were performed separately on the left maxillary sinus tumour and thyroid tumour after complete examination. After tumour resections, the symptoms of bone pain were relieved and the level of blood phosphorus was restored, long-term replacement therapy was needed for thyroid. When a patient is diagnosed with TIO, it is necessary to screen for the presence of other malignant tumours and explore the treatment options in order to benefit patients preferably. AbstractMechanical ventilation as a resource is limited and may lead to poor outcomes in at-risk populations. Critical care supports may not be preferred by those at risk of deterioration in the COVID-19 setting. Patient-centred communication and shared decision-making should continue to remain central to clinical practice.

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Unusual calvarial tumour-oncogenic osteomalacia

Cited by 3 publications

References 5 publications

Occipital bone and tumor-induced osteomalacia: a rare tumor site for an uncommon paraneoplastic syndrome

Occipital bone and tumor-induced osteomalacia: a rare tumor site for an uncommon paraneoplastic syndrome

Tumor induced osteomalacia in head and neck region: single center experience and systematic review

Left maxillary sinus tumour‐induced hypophosphataemic osteomalacia and combined with thyroid papillary carcinoma: a case report and literature review

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