Unusual cases of necrotizing fasciitis: a clinical experience from Turkey

Kapi, Emin; Doğan, Zekeriya; Seyhan, Tamer; Kılınç, Nihal

doi:10.1007/s00238-017-1310-2

Cited by 7 publications

(2 citation statements)

References 36 publications

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“…65 One study by Elliot et al assessing 198 patients reported an average of 4.5 microorganisms per infection and they concluded that the initial regimen should include antibiotics effective against aerobic gram-positive cocci, gram-negative rods, and a variety of anaerobes. 66 An update of the guidelines for the treatment of skin and soft tissue infections published by the Infectious Diseases Society of America (IDSA) in 2014, states that the best choice for a mixed infection is a combination of ampicillin-sulbactam plus ciprofloxacin plus clindamycin. For monomicrobial necrotizing fasciitis, caused by group A streptococci, they report that both clindamycin and penicillin should be used.…”

Section: Medical Managementmentioning

confidence: 99%

“…Elliot et al in their study state that most patients received antibiotic therapy for an average of 12.8 days while other studies propose the administration of the antibiotic agents for up to 5 days after local signs and symptoms have resolved. 4,66 Clinicians should not neglect the fact that patients with NF often present in a condition of sepsis or septic shock; therefore, analgesia, aggressive fluid replacement, nutritional support, and blood pressure support are of utmost importance. 20 Intravenous immunoglobin (IVIG) as antitoxin therapy has also been described recently in literature but there is no strong evidence, to our knowledge, that suggests their beneficial effect in the management of the disease.…”

Section: Medical Managementmentioning

confidence: 99%

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Necrotizing Fasciitis of the Upper Extremity – A Review

Δίτσιος

Chitas

Christidis³

et al. 2022

Orthopedic Reviews

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Necrotizing fasciitis is a soft tissue infection that habitually originates from the fascial sheaths, expands at a volant pace, leads to extensive necrosis of the subcutaneous tissues, and eventually ends up in a life-threatening condition with notably elevated amputation and mortality rates. Factors that induce interruption of skin integrity, such as trauma or intravenous drug use, are the most common inciting events. Specific clinical signs heralding its presence are usually absent in the early stages, often resulting in misdiagnosis. Early recognition, prompt and aggressive surgical debridement, antibiotic use, and supportive care constitute the fundamental principles to lean on for a better prognosis. Necrotizing fasciitis of the upper extremity is relatively rare and consequently holds a limited place in the literature. Only a few studies assess it as a separate entity, with most of them being case reports or small case series. We, therefore, performed a review of the current literature, to assemble the dispersed results of different studies and clarify the various aspects of upper limb necrotizing fasciitis. In this systematic review, we present the epidemiological data, the causative events, the most frequent underlying diseases, the risk factors, the amputation and mortality rates, the pathogenic microorganisms, the clinical characteristics, the diagnostic tools, the medical and surgical management concerning necrotizing fasciitis of the upper limb. Finally, the results indicating its differentiation compared to necrotizing fasciitis of other anatomic sites are remarkably highlighted.

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Section: Medical Managementmentioning

confidence: 99%

Section: Medical Managementmentioning

confidence: 99%