Unusual Cases of Pure Malignant Germ Cell Tumors of the Ovary: A Case Series on 10 Years Experience at a Tertiary Care Center

Abstract

Background: Malignant ovarian germ cell tumors (MOGCTs) are rare female cancers, constituting up to 10% of ovarian cancers. Dysgerminoma is the most common histological variant. Surgical removal of the tumor with optimal debulking is the treatment of choice. Multidrug chemotherapy following surgery offers high remission rates. Considering the prevalence of these tumors in adolescent and young females, fertility-sparing treatment is of paramount importance.
 Methods: The data of all patients with ovarian malignancy admitted at a tertiary-care-teaching hospital from September 2009-March 2019 were analyzed. Ten patients of MOGCTs were treated in this period. The clinical features, radiological and biochemical findings, and management and treatment outcome were evaluated.
 Results: The median age of patients was 23 years. Histological subtypes included immature teratoma (n=3), endodermal sinus tumor (n=4), and dysgerminoma (n=3). Tumor markers namely AFP, βHCG, and LDH increased in all except the patients with immature teratoma. Two patients with dysgerminoma were in the second trimester of pregnancy. All patients except one underwent surgery followed by BEP chemotherapy. Two patients had developed metastasis within six months of treatment and died. In seven patients, no evidence of disease was reported till date.
 Conclusion: Management of antenatal patients with dysgerminoma by surgery followed by BEP chemotherapy has favorable prognosis. Fertility-sparing surgery with adjuvant chemotherapy offers great advantage in young girls. However, risk stratification based on prognostic factors should be implemented in order to individualize the treatment for achieving higher survival rates. The option for oocyte-cryopreser-vation prior to surgery must be discussed with patients desiring future fertlity.

Implantes peritoneales derivados de un teratoma inmaduro con mal apego al tratamiento: reporte de caso

“…Germ cell tumors mainly affect prepubertal and pubertal youth; immature teratomas are frequently associated with ectodermal sinus tumors and dysgerminomas 4 . Within genetic studies, the presence of the Y chromosome has been found in the karyotype of some pediatric patients with gonadal dysgenesis, which is a risk factor for developing a dysgerminoma 5 .…”

Rare case of Rosai–Dorfman disease linked to a mixed malignant tumor with germ cell and central type primitive neuroectodermal components

“…Mixed GCT represents 8% of cases of GCT. 4 They rarely have more than two subtypes. Our patient had four subtypes including yolk sac tumor, embryonal carcinoma, immature teratoma, and dysgerminoma.…”

A Comprehensive Review of Current Trends in the Diagnosis and Treatment of Ovarian Germ Cell Tumors

“…Delays in diagnosis may result in the tumors reaching an advanced stage, limiting treatment options and overall survival. Therefore, understanding the latest trends and advancements in diagnosing and treating these tumors is crucial to improving patient outcomes [ 2 ].…”