Unusual cause of lower extremity wounds: Cobb syndrome

Abstract

Cobb syndrome (Cutaneomeningospinal Angiomatosis) is a rare segmental neurocutaneous syndrome associated with metameric cutaneous and spinal cord arteriovenous malformations (AVMs). In this syndrome, capillary malformation or angiokeratoma-like lesions are formed in a dermatomal distribution, with an AVM in the corresponding segment of the spinal cord. The spinal cord lesions can cause neurological disorder and paraplegia, which typically develop during young adulthood. We report a 32-year-old male with the Cobb syndrome associated with lower extremity painful wounds and acute-onset paraplegia due to metameric vascular malformations.

Malignancy-related Hypercalcemia Caused by Metameric Cutaneous Metastasis of Parathyroid Hormone-related Protein-producing Bladder Carcinoma with Squamous Cell Differentiation: An Autopsy Case of Cobb Syndrome

“…Our patient had experienced acute-onset paraplegia of the lower extremities due to spinal cord paralysis at the time of her pregnancy. Such paraplegia has been reported to be an alarming sign of Cobb syndrome, especially when accompanied by skin lesions in the same metamere ( 14 ). We believed that the onset of symptoms occurred at this time and caused the symptoms.…”