“…All 4 of the patients died, 2 as a result of the space-occupying lesion and 2 as a result of malignancy. This highly lethal tumor has been reported in a number of articles [34][35][36][37][38][39].…”
Section: Central Nervous System Teratomasmentioning
In infancy and childhood, 75% of teratomas occur in females. The most common site is the sacrococcygeal area. The second most common site is the ovary, followed by lesser numbers in many anatomic areas, exclusive of the ex-
“…All 4 of the patients died, 2 as a result of the space-occupying lesion and 2 as a result of malignancy. This highly lethal tumor has been reported in a number of articles [34][35][36][37][38][39].…”
Section: Central Nervous System Teratomasmentioning
In infancy and childhood, 75% of teratomas occur in females. The most common site is the sacrococcygeal area. The second most common site is the ovary, followed by lesser numbers in many anatomic areas, exclusive of the ex-
“…Before the advent of CT scanning, diagnosis was difficult prior to autopsy; surgery was seldom attempted. Sudden neurological deterioration from internal hydrocephalus occurred in four of Takaku's five case presentations, and Hirsh,et al,7 reported that a diagnosis of congenital brain tumor should be considered whenever recurrent shunt malfunction occurs in the hydrocephalic neonate.…”
The authors report the successful total excision of an intracranial teratoma in a neonate. The pathology of this rare tumor and its prognosis in relation to the maturity of individual cell lines is discussed. A review of the previous operation experience in the neonatal age group shows that radical surgical excision of the tumor has seldom been attempted. There are no reported survivors with normal neurological development. The clinical presentation, preoperative evaluation, and operative management are discussed. Emphasis is laid on intensive supportive care in the perioperative period. The difficulty in predicting a benign or malignant course in these tumors justifies extreme caution in making a prognosis and demands careful follow-up supervision. Reoperation is indicated for recurrent benign tumors; malignant germ-cell tumors may respond to combined irradiation and chemotherapy.
“…As of 1977, 57 examples of this lesion were available in the literature 24. The malforma¬ tion associated with this syndrome consists of cystic dilation of the fourth ventricle and agenesis of the cerebel¬ lar vermis.…”
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