Unusual Causes of Ischaemic Stroke and Transient Ischaemic Attack

Warlow, Charles; Gijn, J. van; Dennis, Martin; Bamford, John; Hankey, G.; Sandercock, Peter; Rinkel, Gabriël J.E.; Langhorne, Peter; Sudlow, Catherine; Rothwell, Peter M.

doi:10.1002/9780470696361.ch7

Cited by 3 publications

References 608 publications

(354 reference statements)

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Sildenafil-related cerebral venous sinus thrombosis and papilledema: a case report of a rare entity

et al. 2017

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We present a rare case of cerebral venous sinus thrombosis associated with long-term and high-dose use of sildenafil. A 29-year-old man was referred to our neuroophthalmology clinic for bilateral visual deterioration and severe headache. He had stage 2 papilledema and other clinical and neurological examinations were normal. He had used the drug for nearly 2 years, two to three times a day. All laboratory parameters including blood count cell, coagulation panels, and genetic tests including methylene-tetrahydrofolate reductase and factor V Leiden mutation were unremarkable. The brain magnetic resonance imaging result confirmed transverse cerebral venous sinus thrombosis (CVST). The opening pressure of cerebrospinal fluid (CSF) was 43 cm HO with normal biochemistry and no cells. Clinicians must be aware of the possibility of CVST when the patient uses sildenafil.

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Sildenafil-related cerebral venous sinus thrombosis and papilledema: a case report of a rare entity

et al. 2017

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Chapter 46 Stroke related to systemic illness and complicated surgery

Díez‐Tejedor¹,

Fuentes²

2008

Handbook of Clinical Neurology

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Sildenafil: Can Cause Acute Ischaemic Stroke? A Case Report

Sunumu¹,

Ayas²,

Bölük³

2015

Türk Beyin Damar Hast Derg

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Sildenafil is an inhibitor of phosphodiesterase type-5 (PDE-5), is used for erectile dysfunction. There is not enough information about its effects on the central nervous system Headache, nasal congestion, facial flushing, nausea are the most common side effects. However, neurological complications such as third cranial nerve palsy, transient global amnesia, seizures, cerebral hemorrhage, and infarction are less commonly observed. We present a case of a 60-year-old man with acute ischaemic stroke, which we considered to be interrelated to sildenafil intake. Clinicians must be aware of the possibility of neurological side effects when the patient use sildenafil.

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Unusual Causes of Ischaemic Stroke and Transient Ischaemic Attack

Cited by 3 publications

References 608 publications

Sildenafil-related cerebral venous sinus thrombosis and papilledema: a case report of a rare entity

Sildenafil-related cerebral venous sinus thrombosis and papilledema: a case report of a rare entity

Chapter 46 Stroke related to systemic illness and complicated surgery

Sildenafil: Can Cause Acute Ischaemic Stroke? A Case Report

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