Unusual coincidence of lymphoepithelial cyst and mucinous cystadenoma of the pancreas

Hw, Bernd; Burmester, Eike; Hp, Horny

doi:10.1007/s00428-002-0676-z

Cited by 3 publications

(6 citation statements)

References 4 publications

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“…Histologically, the retention cysts were lined by normal duct epithelium showing focal mucinous metaplasia. It stained for CKs (7,8,18,19), but was negative for CEA and MUC1.…”

Section: Epithelial Nonneoplastic Tumor-like Lesionsmentioning

confidence: 97%

“…Of the MCNs, 10 were classified as adenomas (mean age, 42 years), 8 as borderline tumors (mean age, 39 years) and 14 as carcinomas (mean age, 56 years). One patient simultaneously had a lymphoepithelial cyst [8]. Of [43].…”

Section: Mucinous Cystic Neoplasmsmentioning

confidence: 98%

“…Microscopically, the cysts were lined by mucin-producing cells without atypia. Immunohistochemically, they were positive for CKs (7,8,18,19,20), Ca 19-9 and MUC5AC. There was no malignant transformation (mean follow-up period 2 years).…”

Section: Epithelial Nonneoplastic Tumor-like Lesionsmentioning

confidence: 98%

“…Of the IPMNs, 64 were classified as intestinal type (MUC1/MUC2+ immunophenotype) (Fig. 1b) (7,8,18,19) and b-catenin (membranous pattern) and were negative for a-inhibin, neuron-specific enolase (NSE) and trypsin.…”

Section: Intraductal Papillary-mucinous Neoplasmsmentioning

confidence: 99%

“…A single layer of these cells lined the cyst and produced serous fluid. Immunohistochemically, these cells were found to stain for CKs (7,8,18,19), a-inhibin, MUC6 and usually also for NSE [32] and were negative for trypsin. Staining for b-catenin revealed a membranous reaction.…”

Section: Serous Cystic Neoplasmsmentioning

confidence: 99%

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Cystic neoplasms of the pancreas and tumor-like lesions with cystic features: a review of 418 cases and a classification proposal

et al. 2004

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Although cystic neoplasms and lesions of the pancreas are rare, they have attracted a great deal of attention because of their potential curability. Since, in recent years, several new entities have been identified, the relative frequency of the tumors and their classification need to be reevaluated. In a series of 1454 tumorous lesions of the pancreas collected between 1971 and 2003 in our surgical pathology files and consultation files, all cystic pancreatic neoplasms and tumor-like lesions were identified and typed both histologically and immunohistochemically. There were 418 cases (29%) showing cysts with a diameter ranging between 0.5 cm and 27 cm. Most common were solid pseudopapillary neoplasms (21%) and intraductal papillary-mucinous neoplasms (18%). When only the cystic neoplasms and lesions that had been resected in a single institution were considered, intraductal papillary mucinous neoplasms were the most frequent cystic neoplasms, while solid pseudopapillary neoplasms took fifth place behind ductal adenocarcinomas with cystic features, serous cystic neoplasms and mucinous cystic neoplasms. The most frequent cystic tumor-like lesions were pancreatitis-associated pseudocysts. New and rare entities that have recently been identified are mucinous nonneoplastic cysts, acinar cell cystadenomas and cystic hamartomas. Bearing in mind that figures from referral centers such as ours may be biased regarding the relative frequency of lesions, we concluded from our data that intraductal papillary-mucinous neoplasms are the most frequently occurring pancreatic cystic neoplasms, rather than solid pseudopapillary neoplasms. It was possible to classify all cystic lesions encountered in our files or described in the literature in a new system that distinguishes between neoplastic and nonneoplastic lesions, with further subdivisions into epithelial (adenomas, borderline neoplasms and carcinomas) and nonepithelial tumors. This classification is easy to handle and enables a distinction on the basis of clinical behavior and prognosis.

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“…Histologically, the retention cysts were lined by normal duct epithelium showing focal mucinous metaplasia. It stained for CKs (7,8,18,19), but was negative for CEA and MUC1.…”

Section: Epithelial Nonneoplastic Tumor-like Lesionsmentioning

confidence: 97%

Section: Mucinous Cystic Neoplasmsmentioning

confidence: 98%

Section: Epithelial Nonneoplastic Tumor-like Lesionsmentioning

confidence: 98%

Section: Intraductal Papillary-mucinous Neoplasmsmentioning

confidence: 99%

Section: Serous Cystic Neoplasmsmentioning

confidence: 99%

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Cystic neoplasms of the pancreas and tumor-like lesions with cystic features: a review of 418 cases and a classification proposal

et al. 2004

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Two Cases of Lymphoepithelial Cyst of the Pancreas: First – a Cyst Coexisting with a Primary Gastric Lymphoma, Second – Incidentally Found Pancreatic Cyst

Zielińska-Pająk

Liszka²,

Pająk³

et al. 2008

Z Gastroenterol

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Serous Cystic Neoplasms of the Pancreas

Kosmahl

Wagner

Peters

et al. 2004

The American Journal of Surgical Pathology

137

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Serous cystic neoplasms (SCNs) of the pancreas include serous microcystic adenoma (SMA), serous oligocystic ill-demarcated adenoma (SOIA), solid serous adenoma (SSA), von Hippel-Lindau-associated cystic neoplasm (VHL-CN), and serous cystadenocarcinoma (SCC). These neoplasms are histologically similar but differ in their localization, gross appearance, gender distribution, and biology. A centroacinar origin is assumed but has not been proven. To clarify whether the various subtypes of SCN may be distinguished from each other by marker profiles that might also provide evidence of their origin, the immunoprofiles of 38 SCNs (21 SMAs, 13 SOIAs, 2 VHL-CNs, 1 SSA, and 1 SCC) were defined by applying antibodies against cytoskeletal, neuroendocrine, hormone receptor, and mucin markers. In addition, we examined the expression of calretinin and alpha-inhibin. The various types of SCN showed a very similar immunoprofile, characterized by positivity for cytokeratins and neuron-specific enolase and negativity for vimentin and synaptophysin. Further markers that were commonly expressed in SCNs were alpha-inhibin (SMAs: 76%, SOIAs: 92%, VHL-CNs: 100%), MUC6 (SMAs: 60%, SOIAs: 85%, VHL-CNs: 100%), and MUC1 (SMAs: 24%, SOIAs: 38%, VHL-CNs: 50%). Western blot analysis in one SMA revealed a distinct band that stained with neuron-specific enolase antiserum. Alpha-inhibin was only expressed in 4 of 11 acinar cell carcinomas and not in five ductal adenocarcinomas, five neuroendocrine tumors, one mixed ductal-endocrine carcinoma, and one acinar cell cystadenoma of the pancreas. These results suggest that, despite their biologic differences, the various types of SCNs are composed of the same (or a very similar) cell type and may therefore have a common direction of differentiation. This notion is further supported by the finding that neuron-specific enolase, alpha-inhibin, and MUC6, which may be regarded as new markers for this pancreatic tumor type, were also expressed in most SCNs. Because a number of SCNs share MUC1 and MUC6 expression with the pancreatic centroacinar cells, the possibility of a histogenetic relationship has to be considered.

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Unusual coincidence of lymphoepithelial cyst and mucinous cystadenoma of the pancreas

Cited by 3 publications

References 4 publications

Cystic neoplasms of the pancreas and tumor-like lesions with cystic features: a review of 418 cases and a classification proposal

Cystic neoplasms of the pancreas and tumor-like lesions with cystic features: a review of 418 cases and a classification proposal

Two Cases of Lymphoepithelial Cyst of the Pancreas: First – a Cyst Coexisting with a Primary Gastric Lymphoma, Second – Incidentally Found Pancreatic Cyst

Serous Cystic Neoplasms of the Pancreas

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