Unusual coordinating behavior by three non-steroidal anti-inflammatory drugs from the oxicam family towards copper(II). Synthesis, X-ray structure for copper(II)–isoxicam, –meloxicam and –cinnoxicam-derivative complexes, and cytotoxic activity for a copper(II)–piroxicam complex

Transition metal modified and partially calcined inorganic–organic pillared clays for the adsorption of salicylic acid, clofibric acid, carbamazepine, and caffeine from water

“…5 also shows that the incorporation of transition metals (i.e., Cu 2+ , Co 2+ , or Ni 2+ ) tends to increase the PPCPs adsorption capacities of the IOCs. This result suggested that the adsorbents were plausibly forming stable complexes, these be- tween the aromatic rings of the PPCPs and the transition metal centers, and based on an electron donation and back-donation process similar to the one reported in the literature for synthesis of metal-drug complexes in water, but in the absence of a solid phase [64][65][66]. For salicylic acid, the highest adsorption capacities were observed for NiAlOr-NaBt at natural pH conditions (see Table 1 for pH definitions), followed by CoAlOr-NaBt and CuAlOrNaBt.…”

“…Transition metals are known to undergo complexation with compounds containing aromatic groups based on an electron donation and back donation process. This has been observed during studies related to the interaction of transition metals and drugs and aimed at synthesizing stable new drug complexes in solution [64][65][66]. Since the processes are dominated by weak-chemical interactions, formation of such complexes onto the surface of an adsorbent could provide the basis for the removal of aromatic-like PPCPs while still permitting regeneration via accessible engineering means [67].…”

Tautomeric forms study of 1H-(2′-pyridyl)-3-methyl-5-hydroxypyrazole and 1H-(2′-pyridyl)-3-phenyl-5-hydroxypyrazole. Synthesis, structure, and cytotoxic activity of their complexes with palladium(II) ions

“…All these problems stimulated research for new metal complexes with anticancer activity [3][4][5][6] . Besides the new platinum complexes, the search for better anticancer agents was conducted among complexes of many other metal ions, such as gold(I) and gold(III) 7 , ruthenium(II) and ruthenium(III) 8,9 , copper(II) [10][11][12] , and palladium(II) 13,14 ions. In particular, the palladium ion seems to be interesting, as it exhibits a similar coordination mode to that of the Pt(II) ion, and its complexes also possess square-planar geometry 15 .…”

Synthesis, Characterization, Antimicrobial, DNA cleavage, and Cytotoxicity Studies of Some Metal (II) Complexes of Tridentate Schiff Base Ligand: 2-hydroxy-3-((4-(4-phenylthiazol-2-yl) semicarbazide) methyl) Benzoic Acid

“…They are used as medicines for the treatment of cancer, diabetes, cardiovascular diseases and anti-inflammatory. [20][21][22] The medical application of the metal complexes compounds of thiazole to impart strength, elasticity, and impermeability of water. 23 Analogous of hetero-aromatic Schiff base derived from 3-aldehydosalicylic acid have been to possess biological activity.…”