Unusual extracranial spread of glioblastoma

Thomas, Ricardo J. Fernández-de; Cestero, Joel E Pellot; Cuello, Cesar M Carballo; Jesús, Orlando De

doi:10.1136/bcr-2021-243909

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2023

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(2 citation statements)

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“…In 2009, Kwak and Shatzkes [ 6 ] cited altogether twelve case reports of transdural tumor infiltration from 1962 to 1996. Since then, only a few additional cases have been documented [ 4 , 7 – 9 ].…”

Section: Discussionmentioning

confidence: 99%

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Transdural Skull Base Infiltration by Glioblastoma: Case Report and Review of the Literature

Thrull

Atasi

Boese

et al. 2023

Case Reports in Otolaryngology

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We report the rare occurrence of a temporal glioblastoma multiforme (GBM) showing transdural tumor extension into adjacent mastoid cells. As the dura mater provides a barrier to intraaxial tumors, GBM seldom penetrates into the skull base, even though it is a high-grade astrocytoma with a tendency to spread. Yet, some mechanisms of GBM-induced skull invasion have been identified, making this entity a very rare but nonetheless relevant differential diagnosis in otherwise ambiguous cases of an intracerebral tumor extending into the skull base. In addition, imaging markers that may assist in distinguishing extra- from intraaxial tumor infiltration of the temporal bone are described.

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Section: Discussionmentioning

confidence: 99%

“…The incidence of extraneural metastasis of GBM has been defined as being as low as 0.2% [ 3 ]. Primary transdural skull base infiltration by glioblastoma represents an even rarer finding [ 4 ].…”

Section: Introductionmentioning

confidence: 99%