Unusual gas‐phase hydration efficiency of magnesium–adenosine complex

Frańska, Magdalena; Stężycka, Olga; Ławniczak, Łukasz

doi:10.1002/rcm.8982

Cited by 1 publication

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“…No internal ribose residue loss was observed for the Mg-AMP complex, as indicated by the respective mass spectra shown in the Supporting Information (Figure S7). According to the published mass spectra, no internal ribose residue loss has been observed for the ions [ATP-2H+Na] − and [ATP-H+Mg] + (positive ion) and [nucleotide-H] − . ,− Thus, the conclusion can be drawn that the internal ribose residue loss is a feature characteristic of negatively charged ATP-Mg and ADP-Mg complexes.…”

Section: Resultsmentioning

confidence: 96%

Gas-Phase Internal Ribose Residue Loss from Mg-ATP and Mg-ADP Complexes: Experimental and Theoretical Evidence for Phosphate-Mg-Adenine Interaction

Frańska

Stężycka

Jankowski

et al. 2022

J. Am. Soc. Mass Spectrom.

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Gas-phase decompositions of magnesium complexes with adenosine-5′-triphosphate (ATP) and adenosine-5′-diphosphate (ADP) were studied by using electrospray ionization-collision-induced dissociation-tandem mass spectrometry, in the negative ion mode. The loss of internal ribose residue was observed and was found to occur directly from the [ADP-3H+Mg]− ion. The occurrence of this process indicates the presence of a strong phosphate-Mg-adenine interaction. The performed quantum mechanics calculations confirmed the occurrence of this interaction in the [ADP-3H+Mg]− ion, namely the presence of Mg–N7 bond and hydrogen bond between the phosphate oxygen atom and amino group. Although the finding concerns the gas phase, it indicates that phosphate-Mg-adenine interaction may be also of importance for biological processes. The loss of an internal ribose residue was also observed for calcium and zinc complexes with ATP/ADP as well as for magnesium complexes with guanosine-5′-triphosphate (GTP) or guanosine-5′-diphosphate (GDP). Therefore, it is reasonable to conclude that the presence of the phosphate-metal-nucleobase interaction is a feature of gas phase [NDP-3H+metal]− ion (NDP, nucleoside-5′-diphosphate) and may also be important for biological processes.

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