Unusual haematologic manifestations of Mycoplasma pneumoniae infection

Abstract

A 2-year-old male presented with fever, cervical lymphadenopathy, anaemia, neutrophilia and thrombocytosis. There was no evidence of pulmonary disease. Severe cold antibody (IgM) mediated haemolytic anaemia developed during admission. Infection with Mycoplasma pneumoniae was demonstrated, highlighting the extrapulmonary manifestations of the infection, in the absence of pulmonary signs.

Acute Kidney Injury and Hemolytic Anemia Secondary to <b><i>Mycoplasma pneumoniae</i></b> Infection

“…On the other hand, hemolytic anemia is recognized as a rare but severe complication of Mycoplasma infection. It has been attributed to cross-reacting cold agglutinins, and may be accompanied by renal failure [8,12,13] . Even rarer is the association between Mycoplasma infection and thrombotic throm- bocytopenic purpura or disseminated intravascular coagulation [14,15] .…”

Mycoplasma pneumoniae community-acquired pneumonia (CAP) in the elderly: Diagnostic significance of acute thrombocytosis

“…[17][18][19] This occurred during weeks 1 and 2 of her hospitalization. Her platelet count reached 502 k/mm 3 and slowly decreased over several days during her hospitalization.…”

“…6 -9 In the absence of such findings, the presence of otherwise unexplained acute thrombocytosis may be the only nonspecific laboratory clue to M. pneumoniae CAP. [17][18][19][20] The finding of thrombocytosis should prompt testing for cold agglutinins, if not already ordered, and M. pneumoniae IgM and IgG titers.…”

AN UNUSUAL CASE OF MYCOPLASMA PNEUMONIAE‐ASSOCIATED AUTOIMMUNE HAEMOLYTIC ANAEMIA IN A 10‐YEAR‐OLD FEMALE CHILD

“…[3][4][5][6] However, the use of bisphosphonates in paediatric patients remains controversial because of lack of placebo-controlled clinical trials and safety data. 4 Therefore, many experts recommend limiting use of these agents to those children with recurrent extremity fractures, symptomatic vertebral collapse and reduced bone mass.…”

“…1 On the contrary, anaemia in the majority of children in previous studies is usually self-limited and children recover with supportive care. [2][3][4] The description of this new paediatric case not only emphasises the difficulty of differential diagnosing a child having the aforementioned clinical picture but also the need to conduct larger epidemiological studies concerning the incidence, severity and outcome of extrapulmonary manifestations induced by M. pneumoniae since this clinical entity might be more common than a paediatrician believes.…”