Unusual Immunofluorescence Findings in Pemphigus vegetans

Abstract

An 84-year-old man with massive verrucous lesions in the intertriginous areas is reported. The clinical, histological and electron microscopical findings indicated pemphigus vegetans. However, in addition to the intraepidermal findings direct immunofluorescence showed a linear deposit of IgG and C₃ at the basement membrane.

Pemphigus vegetans of the oral cavity

“…Oral involvement is present in nearly all pemphigus vegetans cases. 4,9 Diagnosis may be difficult because of the varied clinical presentation and the histopathological resemblance of other conditions. 3 The etiopathogenesis of the disease is not clear.…”

“…Indirect immunofluorescence reveals circulating antiepithelial cell-surface IgG. 4,9 Diagnosis may be difficult because of the varied clinical presentation and the histopathological resemblance of other conditions. 10 Differential diagnosis should be especially performed from pyostomatitis vegetans.…”