Unusual Long Absence of Isolated Biliary Atresia in COVID Lockdown

Nomden, Mark; Kleine, Ruben H J de; Bruggink, Janneke L M; Verkade, Henkjan J.; Burgerhof, Johannes G. M.; Hulscher, Jan B F

doi:10.1097/mpg.0000000000003313

Cited by 2 publications

(2 citation statements)

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“…This is in line with previous reports from Texas and Sweden, but in contrast to findings reported in the New York state [10,15,16]. Interestingly, several centers have observed a lower incidence of BA cases during the COVID-19 pandemic, when strict public health guidelines for social distancing, mask-wearing, and frequent handwashing were in place [17]. A study to evaluate BA incidence during the COVID-19 pandemic is currently underway in Europe (European Reference Network RARE LIVER).…”

Section: Geographic Variationssupporting

confidence: 91%

Biliary Atresia in 2021: Epidemiology, Screening and Public Policy

Schreiber

Harpavat

Hulscher

et al. 2022

JCM

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Biliary atresia (BA) is a rare newborn liver disease with significant morbidity and mortality, especially if not recognized and treated early in life. It is the most common cause of liver-related death in children and the leading indication for liver transplantation in the pediatric population. Timely intervention with a Kasai portoenterostomy (KPE) can significantly improve prognosis. Delayed disease recognition, late patient referral, and untimely surgery remains a worldwide problem. This article will focus on biliary atresia from a global public health perspective, including disease epidemiology, current national screening programs, and their impact on outcome, as well as new and novel BA screening initiatives. Policy challenges for the implementation of BA screening programs will also be discussed, highlighting examples from the North American, European, and Asian experience.

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Section: Geographic Variationssupporting

confidence: 91%

Biliary Atresia in 2021: Epidemiology, Screening and Public Policy

Schreiber

Harpavat

Hulscher

et al. 2022

JCM

View full text Add to dashboard Cite

show abstract

“…While correlations between the COVID lockdown and delays in new BA cases have been reported among Dutch centers, we are the first study to have fully detailed, from a national registry, the reduced presentation of BA during the COVID‐19 pandemic (10). This is of concern given the seriousness of the condition, with BA being the most common indication for pediatric LTx (11).…”

Section: Discussionmentioning

confidence: 97%

Reduced Presentation of Biliary Atresia During the COVID-19 Lockdown: A Population Based Observational Study

Arshad¹,

Sutcliffe²,

Jain³

et al. 2023

Journal of Pediatric Gastroenterology &Amp; Nutrition

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Objective: The aim of this study was to assess whether there has been a change in presentations of biliary atresia (BA) in England and Wales during the first and second coronavirus disease 2019 (COVID-19) lockdowns (January–June 2020 and 2021). Design: This population study assessed all confirmed cases of BA, from January 2020 to December 2021 across the 3 UK pediatric liver centers originating from England and Wales. Data was then compared to the incidence of confirmed BA cases from January to December 2017, 2018, and 2019. Results: During January–June 2020 and 2021, there were only 8 and 12 presenting cases of BA in England and Wales, compared to 16, 13, and 18 for the same time periods in 2017, 2018, and 2019, respectively. This difference was significant in a two-sided t test for 2020 (P = 0.035) but not for 2021 (P = 0.385). There was no difference in the mean days to Kasai procedure in January–June 2020 and 2021 compared to 2017–2019; however average time to Kasai after the lockdown periods was significantly higher. Conclusions: There was a significant reduction in the presenting cases of BA during the first COVID-19 lockdown, with an increased time for BA referrals after the pandemic lockdowns were lifted in England and Wales.

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Unusual Long Absence of Isolated Biliary Atresia in COVID Lockdown

Cited by 2 publications

References 1 publication

Biliary Atresia in 2021: Epidemiology, Screening and Public Policy

Biliary Atresia in 2021: Epidemiology, Screening and Public Policy

Reduced Presentation of Biliary Atresia During the COVID-19 Lockdown: A Population Based Observational Study

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