Unusual Metastases of Esophageal Squamous Cell Carcinoma

Chen, Yi‐Hsun; Lin, Chia-Yang; Chen, Yi-Ting; Wu, I-Chen; Wang, Yao‐Kuang

doi:10.1097/rlu.0000000000003927

Cited by 2 publications

(1 citation statement)

References 8 publications

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“…Additionally, some unexpected sites have been reported, such as the skin, eyes, muscles and breasts (3). Table I summarizes the reported cases of colonic metastasis from esophageal SCC (7)(8)(9)(10)(11)(12)(13)(14). To the best of our knowledge, rectal metastasis from esophageal SCC has not been previously reported.…”

Section: Discussionmentioning

confidence: 99%

Rare presentation of esophageal squamous cell carcinoma with rectal metastasis: A case report

Kang,

Zhu,

Yang

et al. 2023

Oncol Lett

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Esophageal cancer is usually diagnosed at an advanced stage, resulting in poor survival. The common sites of distant metastasis include lung, liver and bones. The present study reports a rare case of esophageal squamous cell carcinoma (SCC) with rectal metastasis. A 65-year-old man was diagnosed with middle thoracic esophageal SCC with multiple lymph node metastasis. The patient achieved good response after chemoradiotherapy and adjuvant chemotherapy. During following up, the computed tomography and magnetic resonance scans showed a mass in front of the rectum with intact mucosa. Biopsies were performed and histopathological findings showed SCC, consistent with metastasis from primary esophageal SCC. The patient subsequently received palliative chemoradiotherapy to the rectal tumour and survived for 5 months. To the best of our knowledge, the present case is the first report of metastatic rectal SCC from the esophagus. It is important to take a biopsy of this unexpected lesion for histological analysis, which can help to discriminate metastatic from primary cancer. The goal of treatment is palliative therapy to improve quality of life and survival for this metastatic disease.

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Section: Discussionmentioning

confidence: 99%

Rare presentation of esophageal squamous cell carcinoma with rectal metastasis: A case report

Kang,

Zhu,

Yang

et al. 2023

Oncol Lett

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The roles of G protein-coupled receptor genes and the tumor microenvironment in esophageal squamous cell carcinoma

Shen,

Hu,

Huang

et al. 2024

Oncologie

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Objectives Esophageal squamous cell carcinoma (ESCA) is a challenging disease characterized by a high mortality rate. Understanding the prognostic relationship between G protein-coupled receptors (GPR) and ESCA is critical for improving patient outcomes, yet this connection remains to be fully explored. Methods In this study, we examined the roles of GPR genes and the tumor microenvironment (TME) in ESCA development and progression. Cox regression and Kaplan–Meier analysis demonstrated the predictive value of these genes. Our analysis of TME cell-cell communication revealed extensive interactions, particularly involving neutrophils. We also assessed the combined predictive value of GPR genes, TME score, and tumor mutation burden (TMB) for patient prognosis in ESCA, ultimately constructing a GPR-TME-TMB classifier for prognosis prediction. Results We identified significant differences in GPR gene expression between normal and tumor tissues, with four genes (GPER1, GPR82, FFAR2, and HCAR3) correlating with patient prognosis. Single-cell RNA sequencing analysis revealed 10 major cell types in the TME, with GPR gene expression highly enriched in neutrophils. Our findings indicate that the GPR-TME-TMB classifier is strongly associated with patient prognoses. Additionally, our results align with previous studies on the roles of GPR genes and the TME in ESCA. Conclusions Our results suggest that GPR-related genes play a role in ESCA progression and are strongly associated with TME in ESCA. We constructed a GPR-TME classifier for ESCA to provide new directions for the treatment and prognosis of ESCA patients.

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Unusual Metastases of Esophageal Squamous Cell Carcinoma

Cited by 2 publications

References 8 publications

Rare presentation of esophageal squamous cell carcinoma with rectal metastasis: A case report

Rare presentation of esophageal squamous cell carcinoma with rectal metastasis: A case report

The roles of G protein-coupled receptor genes and the tumor microenvironment in esophageal squamous cell carcinoma

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