Unusual Metastatic Features in a Patient with Concomitant Malignant Orbital Melanoma and Prostate Carcinoma

Abstract

A 73-year-old man with a history of malignant orbital melanoma and prostate carcinoma was admitted for progressive visual disturbance. Brain magnetic resonance imaging showed a suprasellar enhancing nodular lesion with major impingement on the anterior optical ways and sellar invasion. The extensive imaging work-up could not demonstrate with certainty its origin. Surprisingly, the transphenoidal biopsy of this patient revealed a prostate cancer metastasis outlining the importance of a histopathological diagnosis of cerebral metastases in patients with multiple malignancies when there is a doubt about the nature of the lesion.

Metastatic prostate cancer masquerading clinically and radiologically as a primary caecal carcinoma

“…This is best achieved by defining the tumour type on histopathologic grounds and, in this instance, by immunohistochemical staining for PSA[17,30]. The treatment of primary colonic adenocarcinomas is potentially curative with a combination of surgery and chemo-irradiation; treatment of colonic metastasis depends on the primary site and might not be 'curative'.…”

Headache Caused by Brain Metastases of Castration-resistant Prostate Cancer during Cabazitaxel Therapy

“…The detailed treatment course was obtained for eight cases [11][12][13][14][15][16][17][18] in which the brain metastases were sensitive to hormonal therapy. Moreover, 23 cases (18 reports) [19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36] of intracranial metastasis of CRPC were identified. To clarify the characteristics of intracranial metastases of CPRC, these 23 cases are reviewed in Table 1.…”

Multifocal symptomatic intracerebral metastases as the first manifestation of prostatic carcinoma: a report and literature review

“…Symptomatic brain metastases of carcinomas from an unknown primary site mean a neuro-pathological diagnosis is of paramount importance in treating these cases appropriately [5][6][7]. Although prostatic carcinoma is the most commonly detected cancer in men, intracranial metastases have been extremely rare; with epidural localisation being relatively more frequent than intracerebral [8].…”