Unusual Nanofractal Microparticles for Rapid Protein Capture and Release

Song, Yajing; Dong, Xuefang; Shang, Danyi; Zhang, Xiaofei; Li, Xiuling; Liang, Xinmiao; Wang, Shutao

doi:10.1002/smll.202102802

Cited by 13 publications

(20 citation statements)

References 49 publications

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“…Recently, we proposed a strategy of electrostatic interaction regulated emulsion interfacial polymerization to prepare nanofractal polymer microparticles with tunable surface structure. 19 Typically, negatively charged hydrophilic monomers, such as sodium 4-styrenesulfonate (SS), sodium 4-vinylbenzoic (SVBZ), or sodium 4-vinylphenylboronic (SVPB), are introduced into the aqueous phase. Electrostatic repulsion occurs between the charged monomers and newly formed polymers, repelling them from each other.…”

Section: Surface Structure Regulation Of Nanofractal Microparticlesmentioning

confidence: 99%

Heterostructured Microparticles: From Emulsion Interfacial Polymerization to Separation Applications

Song,

Wan,

Wang

2023

Acc. Mater. Res.

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Metrics & MoreArticle Recommendations CONSPECTUS:The development of highly selective materials is a critical task in separation fields because of their increasing importance in environmental treatment, biological medicine, and clinical diagnosis. Polymer microparticles are leading separation materials that have been frequently used for the removal of contaminants from water, extraction of drugs from matrixes, and detection of biomarkers from biofluids. Among existing methods for the preparation of polymer microparticles, emulsion polymerization takes the predominant place due to the good controllability on particle diameter and pore size. Polymer microparticles prepared by emulsion polymerization almost exhibit homogeneous composition. They are competent for the separation of high-concentration species from simple samples but often encounter bottlenecks in the separation of trace species from complex samples. Although surface modification with specific monolayer molecules can improve separation selectivity, unspecific adsorption still exists due to inevitable modification defects. Therefore, the development of novel synthesis methods and separation microparticles is warranted to enable highly selective separation.In recent years, our group has been dedicated to addressing the challenge of the separation of trace species from complex samples by developing next-generation separation microparticles through the innovation of synthesis technologies. We developed the synthesis technology of emulsion interfacial polymerization, prepared a series of new types of polymer microparticles, heterostructured microparticles, and achieved efficient and rapid separation of complex fluidic samples. In this Account, we formally define the concept of "emulsion interfacial polymerization", systematically summarize the recent progress in the physical and chemical parameter regulation for heterostructured microparticles, and comprehensively review related separation applications. In a typical emulsion interfacial polymerization system, an oil-in-water emulsion is established, in which hydrophobic monomers are included in the oil phase, while hydrophilic monomers are included in the aqueous phase. Hydrophobic monomers and hydrophilic monomers copolymerize at the oil−water interface upon initiation, obtaining microparticles with hydrophilic−hydrophobic heterostructures. We show that emulsion interfacial polymerization is a general strategy for the synthesis of heterostructured microparticles with controllable physical and chemical parameters. A series of heterostructured microparticles, including Janus microparticles with tunable topology, heterostructured porous microparticles with tunable pore size, and nanofractal microparticles with tunable surface structures, have been synthesized by rationally regulating the polymerization conditions. Subsequently, we demonstrate that these heterostructured microparticles can be used for various separation systems, including separation of trace microsized oil droplets and organic dyes from water, s...

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Section: Surface Structure Regulation Of Nanofractal Microparticlesmentioning

confidence: 99%

Heterostructured Microparticles: From Emulsion Interfacial Polymerization to Separation Applications

Song,

Wan,

Wang

2023

Acc. Mater. Res.

Self Cite

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Section: Monolayer Modification Strategy and Recent Progressmentioning

confidence: 99%

“…The nanofractal microparticles are believed to provide a 3D contact between functional ionic groups and proteins, enabling a fast protein diffusion rate at the initial capture and release stage. [66] They show great potentials for the rapid separation of biomacromolecules, such as proteins and DNA, in high contrast with totally nanoporous microparticles.…”

Section: Nanofractal Microparticlesmentioning

confidence: 99%

Emerging Nanoporous Materials for Biomolecule Separation

Song

Bao

Shen

et al. 2022

Adv Funct Materials

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Biomolecule separation plays a vital role in downstream applications ranging from omics research, structure analysis, and drug purification to clinical diagnosis. Among all existing materials and technologies towards biomolecule separation, nanoporous materials take the leading place. To achieve efficient biomolecule separation, the interface of nanoporous materials is always modified with a monolayer containing specific functional groups. However, the monolayer modification strategy still encounters bottlenecks due to extremely low abundance of target biomolecules, strong interference from high‐abundance background biomolecules, similar characteristics of compounds, unspecific adsorption, et al. Recently, several emerging nanoporous materials, which are prepared without the monolayer modification process, have been reported for high‐efficient, high‐specific, and rapid biomolecule separation. In this review, the authors summarize the emerging nanoporous materials for biomolecule separation, mainly focusing on the design principle and separation performance that are different from classical nanoporous materials. First, the classic design strategy of monolayer modification is discussed and the recent progress with this aspect is introduced. Then, emerging nanoporous materials beyond monolayer modification are introduced. At last, future developments, challenges, and great promise of biomolecule separation nanoporous materials are discussed.

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“…These 3D nanostructures have increased specific surface area to provide more EV binding sites than those without secondary structures. As a result of enhanced interactions between the microfluidic device and EVs, the EV capture efficiency has been improved as well [72][73][74][75][76].…”

Section: Microfluidic Devices With Incorporated 3d Nanostructure Arra...mentioning

confidence: 99%

Recent progress on microfluidic devices with incorporated 1D nanostructures for enhanced extracellular vesicle (EV) separation

et al. 2022

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Unusual Nanofractal Microparticles for Rapid Protein Capture and Release

Cited by 13 publications

References 49 publications

Heterostructured Microparticles: From Emulsion Interfacial Polymerization to Separation Applications

Heterostructured Microparticles: From Emulsion Interfacial Polymerization to Separation Applications

Emerging Nanoporous Materials for Biomolecule Separation

Recent progress on microfluidic devices with incorporated 1D nanostructures for enhanced extracellular vesicle (EV) separation

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