Unusual Ocular Manifestations of Dengue Fever in a Young Girl

Chhavi, Nanda; Chandrasekaran, Venkatesh; Palanisamy, S.; Gunasekaran, Dhandapany

doi:10.1007/s12098-012-0871-0

Cited by 11 publications

(4 citation statements)

References 4 publications

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“…Intermediate uveitis is present in approximately 12.3% of cases and can co-occur with anterior uveitis in 11%. Adequate steroid response is reported in such cases [66,71,73].…”

Section: Ocular Signs and Symptomsmentioning

confidence: 99%

Dengue Fever: Ophthalmological Perspective

Hernandez-Delgado¹,

Salvador-Galvez²,

Garcia³

2021

Int J Trop Dis

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“…Intermediate uveitis is present in approximately 12.3% of cases and can co-occur with anterior uveitis in 11%. Adequate steroid response is reported in such cases [66,71,73].…”

Section: Ocular Signs and Symptomsmentioning

confidence: 99%

Dengue Fever: Ophthalmological Perspective

Hernandez-Delgado¹,

Salvador-Galvez²,

Garcia³

2021

Int J Trop Dis

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“…Ophthalmic symptoms emerge in the form of anterior uveitis, pan-uveitis, retinitis, retinal hemorrhages, maculopathy, optic neuropathy, and corneal epitheliopathy [3][4][5]. Over the last few years, intense versions of ocular and orbital manifestations have additionally been documented, like necrotizing scleritis and panophthalmitis [6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Ophthalmic manifestations as the first presenting feature in dengue fever: a 10-year study

2024

RJO

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Purpose: To report patients who first presented with various ocular manifestations and eventually ascertained to have underlying dengue. Methods: A prospective study was conducted at multiple tertiary eye-care centers in India from 2012 to 2022. Cases reporting initially with ocular features along with fever/past history of fever over the last two weeks or with clinical features of dengue were selected. After an ophthalmological examination, patients underwent complete serological and biochemical analysis and those with reduced platelet counts were evaluated for dengue. Results: Out of 564 cases, 15 patients were verified to be afflicted with dengue eventually. A rising trend of cases was seen every year and out of 15 cases, eight cases were reported during the Covid-19 pandemic (from 2020 to 2022), but were COVID-negative. 9 cases presented with acute redness followed by diminished vision. Seven cases presented a history of fever over the last few days and one had traveled from dengue endemic area. The various ocular presentations included subconjunctival hemorrhage, viral keratitis, anterior uveitis, sixth-nerve palsy, and vitreous hemorrhage. On serological examination, all 15 patients were detected to have low platelets. All cases responded well with supportive treatment and the ocular features subsided in all within a couple of weeks with good visual recovery. Conclusion: In a tropical nation, such as India, with endemic dengue zones and increasing figures of dengue lately, ophthalmologists must include dengue fever among the differential diagnoses in various ocular presentations like subconjunctival hemorrhage, viral keratitis, anterior uveitis, sixth nerve palsy, and vitreous hemorrhage. Abbreviations: DHF = dengue hemorrhagic fever, PCR = polymerase chain reaction, RT-PCR = real-time automated reverse transcriptase (RT-PCR), SD = standard deviation, MAC-ELIS = IgM antibodies capture enzyme-linked immunosorbent assay, RE = right eye, LE = left eye, CECT = Contrast-enhanced computed tomography

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“…The anterior segment manifestations include periorbital ecchymosis, subconjunctival hemorrhage, bilateral punctate corneal erosions, and anterior uveitis while the posterior segment involvement which is commoner can present as intermediate uveitis, maculopathy (foveolitis), retinal vasculitis, retrobulbar hemorrhage, isolated peripheral hemorrhage, vitreous hemorrhage, sub-hyaloid hemorrhage, and Roth spots. [ 3 4 ] A plethora of studies on the host–virus interactions to understand the systemic pathogenesis in humans has been published, however, the literature is bereft of publications on DENV and its role in ocular diseases. [ 5 ] Similarly, cellular and molecular mechanisms to understand systemic dengue have been extensively studied, but on the literature search, no publications of DENV in vitro or in vivo to understand the disease pathology, risk factors for eye disease, and preventive measures could be found.…”

mentioning

confidence: 99%

Evidence of dengue virus in eviscerated specimens of panophthalmitis secondary to dengue fever: A possible cause-effect phenomenon

Dave

Sharma

Lakshmi

et al. 2022

Indian Journal of Ophthalmology

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Purpose: To report a retrospective series of three cases of infectious panophthalmitis post-dengue fever with ex vivo confirmation of dengue virus ribonucleic acid (RNA) in the tissues of the eye. Methods: Four eyes of three patients, who were diagnosed with panophthalmitis following dengue fever and who underwent evisceration, were included. All demographic and clinical data were recorded. The eviscerated samples were subjected to direct microscopy, culture for bacteria, fungi, and parasites, and molecular virology (dengue virus [DENV] NS1-specific reverse transcription loop-mediated isothermal amplification (RT-LAMP) assay). Results: The time from the development of dengue fever to the occurrence of ocular symptoms was 4.33 ± 1.15 (median 5) days. DENV NS1 RNA, suggestive of the presence of the dengue virus, was confirmed in all evisceration specimens (uveal tissue, cornea). All the patients recovered completely from dengue fever and on follow-up had healthy eviscerated sockets. Conclusion: Demonstration of the DENV RNA in the eviscerated specimens of panophthalmitis following dengue fever implicates the DENV in the pathophysiology of the ocular infection.

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Unusual Ocular Manifestations of Dengue Fever in a Young Girl

Cited by 11 publications

References 4 publications

Dengue Fever: Ophthalmological Perspective

Dengue Fever: Ophthalmological Perspective

Ophthalmic manifestations as the first presenting feature in dengue fever: a 10-year study

Evidence of dengue virus in eviscerated specimens of panophthalmitis secondary to dengue fever: A possible cause-effect phenomenon

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