Unusual ocular motor findings in multiple sclerosis

Seze, J. de; Vukusic, Sandra; Viallet-Marcel, M.; Tilikete, Caroline; Zephir, Hélène; Delalande, S.; Stojkovic, Tanya; Defoort‐Dhellemmes, Sabine; Confavreux, Christian; Vermersch, Patrick

doi:10.1016/j.jns.2005.11.022

Cited by 41 publications

(24 citation statements)

References 25 publications

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“…It is well delineated that the pursuit system is sufficiently sensitive to evaluate the dynamic aspect of eye movement [11,15]. Practically all types of eye movement disorders have been described in MS patients [2,5,9,15]. In bedside examination we observed not only abnormalities in clinical smooth pursuit test, but also up and down beating nystagmus, gaze evoked nystagmus and signs of internuclear ophthalmoplegia.…”

Section: Discussionmentioning

confidence: 70%

“…Hence, the symptoms observed in an individual patient will depend on localization and degree of demyelination. Randomly located lesions involve large part of the central nervous system and may disturb oculomotor activity [1][2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

“…Deficits in eye movement are frequently observed in MS patients, including impairment of the saccadic and pursuit system, internuclear ophtalmoplegia signs, vestibulo-ocular reflex or voluntary gaze abnormalities (30-75%) in particular [1,2,5,9,10].…”

Section: Introductionmentioning

confidence: 99%

“…Smooth pursuit tests evaluate the mechanism coordinating eye movements generated and controlled by brainstem reticular formation and cerebellum. This test in combination with functional imaging and transcranial magnetic stimulation has become a useful tool to study eye motor control, cognition and memory [5,[11][12][13]. It shows dynamic eye movement properties and gives information about the status of central control of these movements [14,15].…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of the smooth pursuit tests in multiple sclerosis patients

Józefowicz-Korczyńska

Pajor

2011

J Neurol

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In multiple sclerosis (MS), randomly located demyelination lesions may involve a large part of the central nervous system and disturb oculomotor activity, including impairment of saccadic and pursuit systems. The aim of the work was to determine the frequency of smooth pursuit disturbances in MS patients and assess the feasibility of various methods for smooth pursuit assessment: the clinical bedside examination and quantitative electrooculographic (EOG) recordings. In addition, we analyzed the effects of age on the results of smooth pursuit tests. Sixty MS patients and 50 volunteers underwent clinical bedside examination and EOG evaluation in a tertiary referral university hospital. EOG recordings of smooth pursuit tests with 0.3, 0.4, 0.5 and 15 Hz amplitude and gain calculation were preformed. In clinical bedside examination, disorders were found in 25%, and with EOG in 76.6% of patients. In the MS patients and subgroups the mean gain for all frequencies were significantly lower compared with the control group. There were significant differences in gain between younger and older subjects in the control group but no significance in all MS patients their subgroups. Patients with abnormalities in clinical bedside examination had poorer results in EOG tests. There were correlations between gain values and Expanded Disability Status Scale score in MS patients. Smooth pursuit examination provides a valuable parameter of brain dysfunction in MS patients. The EOG test is more useful in detecting subclinical cases than clinical bedside examination, and is not affected by test paradigm or age in MS patients.

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Section: Discussionmentioning

confidence: 70%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Evaluation of the smooth pursuit tests in multiple sclerosis patients

Józefowicz-Korczyńska

Pajor

2011

J Neurol

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show abstract

“…No consistent structural lesions of brain stem or cerebellum have been found in patients with opsoclonus. Opsoclonus is occasionally seen with focal structural lesions [9][10][11], but the lesions are not localized to a single structure and the same structures are not consistently involved. In the majority of cases, as in our cases, MRI of the brain is normal.…”

Section: Discussionmentioning

confidence: 99%